益生菌联合抗生素对抗生素相关性腹泻新生儿肠道菌群的影响  

Effect of probiotics combined with Ceftizoxime sodium on intestinal flora in neonates with antibiotic associated diarrhea

作　　者：曹珍珍[1] 刘增芳 贺兆平 马宁[1] CAO Zhen-zhen;LIU Zeng-fang;HE Zhao-ping;MA Ning(Pediatric Department,Yulin No.2.Hospital,Yulin,Shaanxi 719000,China;不详)

机构地区：[1]榆林市第二医院儿科,陕西719000

出　　处：《中国微生态学杂志》2021年第7期806-809,共4页Chinese Journal of Microecology

摘　　要：目的探讨酪酸梭菌二联活菌散剂联合头孢唑肟钠对抗生素相关性腹泻新生儿肠道菌群的影响。方法选取2017年1月至2019年12月期间我院收治的80例抗生素相关性腹泻新生儿为研究对象,采用随机数字法将其分为对照组(n=40)与观察组(n=40)。对照组患儿采用头孢唑肟钠治疗,观察组在对照组的基础上联合酪酸梭菌二联活菌散剂治疗,治疗72 h后比较两组患儿治疗效果及肠道菌群数量。结果治疗72 h后,观察组患儿肠鸣音恢复时间、腹痛缓解时间、腹泻消失时间、腹胀消失时间及住院时间均短于对照组(t=7.873、6.807、5.096、4.977、4.794,均P<0.001),临床有效率高于对照组(95.00%vs 82.50%,χ^(2)=4.486,P=0.034)。治疗72 h后,观察组患儿肠道大肠埃希菌数量低于对照组(t=3.924,P<0.001),而乳杆菌、双歧杆菌数量均高于对照组(t=2.169、3.016,P=0.033、0.003)。结论酪酸梭菌二联活菌散剂联合头孢唑肟钠可通过改善肠道菌群数量发挥治疗新生儿抗生素相关性腹泻的效果。Objective To observe the effect of Clostridium butyricum and Bifidobacterium powder combined with Ceftizoxime sodium on intestinal flora in neonates with antibiotic associated diarrhea(AAD). Methods Eighty neonates with AAD admitted to our hospital from January 2017 to December 2019 were randomly divided into control group(n=40) or observation group(n=40). Ceftizoxime sodium was used in both groups;the observation group was additionally given Clostridium butyricum and Bifidobacterium powders on the basis of the control group.After 72 hours, the therapeutic effect and intestinal flora were compared between groups. Results The time to recovery of bowel sounds, time to remission of abdominal pain, time to disappearance of diarrhea, time to disappearance of abdominal distention and hospitalization time in the observation group were shorter than those in the control group respectively(t=7.873, 6.807, 5.096, 4.977, 4.794;all P<0.001). The clinical efficiency rate in the observation group was higher than that in the control group(95.00% vs 82.50%, χ^(2)=4.486,P=0.034). The content of Escherichia coli in the observation group was lower(t=3.924,P<0.001), while those of Lactobacillus and Bifidobacterium were higher than those in the control group,respectively(t=2.169, 3.016;P=0.033, 0.003). Conclusion Clostridium butyricum and Bifidobacterium powder combined with Ceftizoxime sodium can improve the content of intestinal flora and play a role in the treatment of antibiotic associated diarrhea.

关 键 词：酪酸梭菌二联活菌散剂 头孢唑肟钠 抗生素相关性腹泻 新生儿 肠道菌群 

分 类 号：R272.1[医药卫生—中医儿科学]