卵巢癌患者术后阴道微生态分析  

Vaginal microecology in postoperative patients with ovarian cancer

作　　者：张伟 孙莉[2] 胡丽庆[3] 王微微 侯伟伟[5] 刘静[6,7] 商安全 ZHANG Wei;SUN Li;HU Li-qing;WANG Wei-wei;HOU Wei-wei;LIU Jing;SHANG An-quan(Department of Laboratory Medicine,Jiaozuo Fifth People′s Hospital,Jiaozuo,Henan 454000,China;不详)

机构地区：[1]焦作市第五人民医院检验科,河南454000 [2]襄阳职业技术学院医学院 [3]宁波市第一医院检验科 [4]盐城市第六人民医院实验诊断科 [5]上海同济大学附属同济医院检验科 [6]南京大学医学院附属鼓楼医院妇产科 [7]盐城市盐都区第二人民医院妇产科

出　　处：《中国微生态学杂志》2021年第7期832-835,共4页Chinese Journal of Microecology

基　　金：国家自然科学基金(81802084);江苏省卫生健康委员会医学科研项目(2019179);2017年焦作市医学科研项目(2017KY057);盐城市医学科技发展计划项目(YK2017120,YK2017121,YK2019112);盐城市医学重点人才项目。

摘　　要：目的对卵巢癌患者术后阴道微生态特征进行回顾性分析,为临床预防及诊疗提供参考。方法选取158例卵巢癌术后患者为卵巢癌组,150例同期健康体检者为对照组,对留取样本进行革兰染色镜检及阴道五项联检检测,并对阴道微生态结果进行统计分析。结果卵巢癌组阴道五联检各指标异常率高于对照组(均P<0.05)。革兰染色油镜镜检联合五联检判断的阴道微生态结果显示卵巢癌组在优势菌、菌群多样性、密集度、细菌性阴道病、需氧菌性阴道炎、外阴阴道假丝酵母菌病、混合感染异常率方面高于对照组(均P<0.05)。2组研究对象滴虫性阴道炎感染差异无统计学意义(P>0.05)。结论卵巢癌患者术后阴道菌群失调率较高,临床应对卵巢癌术后患者阴道菌群定期进行监测,减少感染发生。Objective To retrospectively analyze the vaginal microecological characteristics of ovarian cancer patients after surgery and provide reference for clinical prevention and treatment. Methods A total of 158 cases of postoperative ovarian cancer were selected as ovarian cancer group, 150 cases of health check-ups were selected as control group. The remained samples were examined by using Gram staining microscopic examination and joint detection of five vaginal indexes. The results were statistically analyzed. Results The abnormal rates by the joint detection of five vaginal indexes in ovarian cancer group was higher than that in control group(P<0.05). Gram staining microscopic examination and joint detection of five vaginal indexes showed that the abnormal rates in dominant bacteria, flora diversity, density, Bacterial vaginosis, Aerobic vaginitis, Vaginal candidiasis and mixed infection in ovarian cancer group were higher than those in control group respectively(all P<0.05). There was no significant difference in Trichomonas vaginitis infection between the two groups(P>0.05). Conclusion Vaginal flora imbalance rate is high in patients with ovarian cancer after operation. Clinically, vaginal flora of patients with ovarian cancer after operation should be monitored regularly to reduce the occurrence of infection.

关 键 词：卵巢癌 阴道微生态 阴道菌群 

分 类 号：R378[医药卫生—病原生物学]