载脂蛋白E等位基因多态性对徐州地区高血压患者的影响  

Effect of apolipoprotein E allele polymorphism on hypertension patients in Xuzhou area

作　　者：李磊 孔倩倩 钮威 王丽[2] 牛璐璐 余汉忠 LI Lei;KONG Qianqian;NIU Wei;WANG Li;NIU Lulu;YU Hanzhong(Department of Clinica Laboratory,the Third People′s Hospital of Xuzhou,Xuzhou,Jiangsu 221000,China;Department of Clinica Laboratory,China University of Mining/Xuzhou First People′s Hospital,Xuzhou,Jiangsu 221009,China)

机构地区：[1]江苏省徐州市第三人民医院检验科,江苏徐州221000 [2]中国矿业大学/江苏省徐州市第一人民医院检验科,江苏徐州221009

出　　处：《检验医学与临床》2021年第16期2332-2334,共3页Laboratory Medicine and Clinic

基　　金：江苏省徐州市科技计划项目(KC18169);2020年中国矿业大学青年科技基金(第二批)项目(2020QN92)。

摘　　要：目的探讨载脂蛋白E(ApoE)等位基因多态性对徐州地区高血压患者的影响。方法选取徐州地区临床确诊的高血压患者97例作为高血压组,另选取106例非高血压患者作为对照组。应用PCR-荧光探针法对2组ApoE基因型分别进行检测并统计分析检测结果。结果ApoE表型和ApoE等位基因频率在2组患者中的表达差异无统计学意义(P>0.05)。在高血压人群中,ε4等位基因携带者的收缩压较其他等位基因携带者高(P<0.05),而ApoE基因多态性对舒张压影响不大(P>0.05)。结论徐州地区ApoE表型和ApoE等位基因频率与高血压疾病无关,ApoE等位基因ε4可能是高血压发生、发展的危险因素。Objective To explore apolipoprotein E(ApoE)allele polymorphism and its relationship in patients with hypertension.Methods Totally 97 patients with hypertension in Xuzhou were selected as hypertension group,and 106 patients without hypertension were selected as control group.The genotypes of ApoE in the two groups were detected by PCR fluorescence probe method,and the results were analyzed statistically.Results There was no significant difference in the expression of ApoE phenotype and allele frequency between the two groups(P>0.05).In people with high blood pressure,the systolic blood pressure of theε4 allele carriers was higher than that of the other alleles(P<0.05),but the ApoE gene polymorphism had little effect on diastolic blood pressure(P>0.05).Conclusion The phenotype and allele frequency of ApoE are not associated with hypertension in Xuzhou area,ApoE alleleε4 may be a risk factor for the occurrence and development of hypertension.

关 键 词：载脂蛋白E 基因频率 表型 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]