替米沙坦对2型糖尿病合并高血压患者胰岛素抵抗及氧化应激水平的影响  

Effect of telmisartan on insulin resistance and oxidative stress levels in patients with type 2 diabetes and hypertension

作　　者：刘继红 王乾了[2] 程汝兰 张洪福[2] 叶丽萍[2] 王晓玲[2] 黄建平[2] LIU Jihong;WANG Qianliao;CHENG Rulan;ZHANG Hongfu;YE Liping;WANG Xiaoling;HUANG Jianping(The Health Physical Examination Center,North-Kuanren General Hospital,Chongqing 401121,China;Department of Nephrology,Shifang People′s Hospital,Shifang,Sichuan 618400,China)

机构地区：[1]重庆北部宽仁医院体检中心,重庆401121 [2]四川省什邡市人民医院肾内科,四川什邡618400

出　　处：《检验医学与临床》2021年第16期2350-2352,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨替米沙坦对2型糖尿病合并高血压患者胰岛素抵抗及氧化应激水平的影响。方法将四川省什邡市人民医院2012年1月至2013年6月收治的60例2型糖尿病合并高血压患者分为治疗组和对照组,每组30例,分别给予替米沙坦(80 mg,每天1次)、硝苯地平(10 mg,每天2次)治疗24周。检测并观察2组患者空腹血糖、空腹胰岛素、胰岛素抵抗指数(HOMA-IR)、氧化应激指标[血浆硫氧还蛋白(TRX)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)]的水平变化。结果用药24周后,治疗组空腹血糖、HOMA-IR较用药前降低(P<0.05),空腹胰岛素水平较用药前升高(P<0.05);治疗组TRX、SOD、CAT水平较对照组升高,差异均有统计学意义(P<0.05);治疗组MDA水平较对照组降低,差异有统计学意义(P<0.05)。治疗前,2组间空腹血糖、空腹胰岛素、HOMA-IR比较,差异无统计学意义(P>0.05),治疗24周后,治疗组空腹血糖、HOMA-IR较对照组降低,差异有统计学意义(P<0.05);治疗组空腹胰岛素水平较对照组升高,差异有统计学意义(P<0.05)。结论替米沙坦可以改善2型糖尿病合并高血压患者的胰岛素抵抗,这可能与减轻氧化应激损伤有关。Objective To explore the effect of telmisartan on insulin resistance and oxidative stress levels in patients with type 2 diabetes and hypertension.Methods Sixty patients with type 2 diabetes and hypertension from January 2012 to June 2013 in the Shifang People′s Hospital were divided into treatment group and control group,30 patients in each group were given telmisartan(80 mg,once a day)and nifedipine(10 mg,twice a day),treatment for 24 weeks.Fasting blood glucose,fasting insulin,insulin resistance index(HOMA-IR)and oxidative stress indexes,including plasma thioredoxin(TRX),superoxide dismutase(SOD),catalase(CAT)and malondialdehyde(MDA)were observed.Results After 24 weeks of treatment,fasting blood glucose and HOMA-IR in the treatment group were lower than those before treatment(P<0.05),and fasting insulin level was higher than that before treatment(P<0.05);the levels of TRX,SOD and CAT in the treatment group were significantly higher than those in the control group(P<0.05);the MDA level of the treatment group was lower than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in fasting blood glucose,fasting insulin and HOMA-IR between the two groups(P>0.05).After 24 weeks of treatment,fasting blood glucose and HOMA-IR in the treatment group were lower than those in the control group(P<0.05);the fasting insulin level in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Telmisartan can improve insulin resistance in patients with type 2 diabetes mellitus and hypertension,which may be related to alleviating oxidative stress injury.

关 键 词：替米沙坦 2型糖尿病 胰岛素抵抗 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]