慢性阻塞性肺疾病的临床特征及动脉硬化程度与气道阻塞的相关性  

Clinical characteristics of patients with chronic obstructive pulmonary disease and correlation between arterial stiffness and airway obstruction

作　　者：张胜涛 张晓辉[2] 刘鹏[3] 王静[3] 黄秋玲 ZHANG Shengtao;ZHANG Xiaohui;LIU Peng(Department of Ultrasound Diagnosis,Linxi Hospital of Kailuan General Hospital,Hebei,Tangshan 063100,China;不详)

机构地区：[1]开滦总医院林西医院超声诊断科,河北省唐山市063100 [2]开滦总医院林西医院呼吸内科,河北省唐山市063100 [3]开滦总医院林西医院儿科,河北省唐山市063100

出　　处：《河北医药》2021年第16期2511-2514,共4页Hebei Medical Journal

基　　金：河北省医学科学研究课题计划项目(编号:20191343)。

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者的临床特征及其动脉硬化程度与气道阻塞的相关性。方法回顾性分析2018年1月至2019年12月88例COPD患者的临床资料(研究组),另纳入96例肺功能正常的体检者作为对照(对照组),比较2组研究对象的临床资料,肺功能,颈动脉超声,外周动脉硬化等指标。结果研究组有吸烟史的比例明显高于对照组(P<0.05)。研究组TC,TG,HDL-C、FEV1、FEV1/FVC水平均明显低于对照组,LDL-C,肌酐和Hcy水平明显高于对照组(P<0.05)。研究组hs-CRP,TNF-α和IL-6水平明显高于对照组(P<0.05)。研究组RI,PI,IMT以及斑块检出率均明显高于对照组,且2组IMT超声分型存在明显差异(P<0.05)。研究组baPWV和ABI均明显高于对照组(P<0.05)。FEV1/FVC、FEV1均与baPWV呈负相关(r=-0.516,r=-0.522,P<0.05)。hs-CRP、TNF-α、IL-6均与baPWV呈正相关(r=0.588,r=0.625,r=0.534,P<0.05)。结论COPD可能促进动脉硬化的发生,COPD患者应加强动脉硬化的筛查,提早发现并干预,从而降低心血管疾病风险。Objective To investigate the clinical characteristics of patients with chronic obstructive pulmonary disease(COPD)and correlation between arterial stiffness and airway obstruction.Methods Eighty-eight COPD patients who were treated from January 2018 to December 2019 were enrolled as research group,and the other 96 subjects with normal pulmonary function were taken as control group.The clinical data,pulmonary function,carotid ultrasound,peripheral arteriosclerosis and other indicators were observed and compared between the two groups.Results The proportion of smoking history in resarch group was significantly higher than that in control group(P<0.05).The levels of TC,TG,HDL-C,FEV1,FEV1,FVC in research group were significantly lower than those in control group,but the levels of LDLC,creatinine and Hcy were significantly higher than those in control group(P<0.05).Moreover,The levels of hs-CRP,TNF-αand IL-6 in research group were significantly higher than those in control group(P<0.05).Furthermore,the levels of RI,PI,IMT and detection rate of plaque in research group were significantly higher than those in control group,and there was significant difference in the ultrasonic classification of IMT between the two groups(P<0.05).In addition,the levels of baPWV and ABI in research group were significantly higher than those in control group(P<0.05).FEV1/FVC and FEV1 were negatively correlated with baPWV(P<0.05).Hs-CRP,TNF-αand IL-6 were positively correlated with baPWV(P<0.05).Conclusion COPD may promote the occurrence of atherosclerosis.It is necessary to strengthen the screening of arteriosclerosis,early detection and intervention for patients with COPD,so as to decrease the risk of cardiovascular disease.

关 键 词：慢性阻塞性肺疾病 动脉硬化 超声 临床特征 相关性 

分 类 号：R563[医药卫生—呼吸系统]