血小板衍生因子A的生理功能研究进展  

Research Advances on Physiological Functions of Platelet-derived Growth Factor A

作　　者：吴子贤 李蕴华 张斌 张军 赵艳红[4] 刘佳森 WU Zi-xian;LI Yun-hua;ZHANG Bin;ZHANG Jun;ZHAO Yan-hong;LIU Jia-sen(Animal Husbandry Institute,Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China;Livestock Improvement Workstation of Wuchuan County,Wuchuan011700,China;Center for Animal Disease Control and Prevention of Hanggin Banner of Ordos City,Hanggin Banner 017400,China;Inner Mongolia Key Laboratory of Animal Genetics,Breeding and Reproduction,College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China)

机构地区：[1]内蒙古自治区农牧业科学院畜牧研究所,内蒙古呼和浩特010031 [2]武川县家畜改良站,内蒙古武川011700 [3]鄂尔多斯市杭锦旗动物疫病预防控制中心,内蒙古杭锦旗017400 [4]内蒙古农业大学动物科学学院/内蒙古自治区动物遗传育种与繁殖重点实验室,内蒙古呼和浩特010018

出　　处：《畜牧与饲料科学》2021年第4期49-53,109,共6页Animal Husbandry and Feed Science

基　　金：国家自然科学基金项目(31560624);内蒙古自然科学基金项目(2020LH03020,2015MS0381);内蒙古农牧业科技创新基金项目(2017CXJJM01-3)。

摘　　要：血小板衍生因子A(platele-derived growth factor A,PDGFA)是PDGF家族中的一种多肽,具有促进细胞生长、刺激细胞与细胞间质相互作用、影响毛囊生长的功能。从PDGFA的蛋白结构、主要基因表达通路Wnt、SHH、BMP和在皮肤、肺部以及绒毛生长中的作用进行综述,探讨PDGFA在毛囊生长和周期维持中发挥的重要作用,以期为进一步研究绒毛生长机理提供参考。Platelet-derived growth factor A(PDGFA)is a kind of polypeptides in the PDGF family,which has the functions of promoting cell growth,stimulating the interactions between cells and intercellular substances,and influencing wool follicle growth.This paper reviews the protein structure of PDGFA,the main expression pathways of Wnt,SHH and BMP of PDGFA,and the roles of PDGFA in skin,lung and wool growth.Furthermore,the important roles of PDGFA in wool follicle growth and cycle maintenance are elaborated,in hoping to provide a basis for further researches on mechanisms of wool growth.

关 键 词：PDGFA基因 结构和表达 表达通路 生理功能 毛囊生长 

分 类 号：Q592.1[生物学—生物化学]