323例抗菌药物致药物热的文献计量研究  

Bibliometric research on 323 cases of drug fever induced by antimicrobial

作　　者：杨越 白延宁 张媛媛[3] 乔逸 杨瑞霞[1] 杨志福 孙宝 YANG Yue;BAI Yan-ning;ZHANG Yuan-yuan;QIAO Yi;YANG Rui-xia;YANG Zhi-fu;SUN Bao(Department of Pharmacy,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,China;Department of Cli-nical Pharmacy,Yanan University Affiliated Hospital,Yanan 716000,China;Department of Pharmacy,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712030,China;Department of Pharmacy,Xijing Hospital,Air Force Medical university,Xi’an 710032,China)

机构地区：[1]西安医学院第二附属医院药剂科,西安710038 [2]延安大学附属医院临床药学科,陕西延安716000 [3]陕西中医药大学第二附属医院药剂科,咸阳712030 [4]空军军医大学西京医院药剂科,西安710032

出　　处：《实用药物与临床》2021年第8期722-726,共5页Practical Pharmacy and Clinical Remedies

基　　金：国家自然科学基金(81573549)。

摘　　要：目的探讨抗菌药物所致药物热的临床表现、一般规律和特点,为临床合理、安全用药提供参考。方法以关键词检索1980-2019年中国知网、万方、维普数据库,对其报道的抗菌药物引起药物热的个案报道进行分析。结果共检索到239篇文献,323例个案报道。男性多于女性,以18~44岁年龄段分布最多,共132例(40.87%);原患疾病中以呼吸系统疾病为主,共153例次(38.25%);引起药物热的药物中主要为头孢菌素类药物,共67例次(20.74%);药物热出现的时间2~7 d内最多,共110例次(34.06%);以高热为主,187例次(57.90%);伴发的临床症状中全身累及最为广泛,共104例次(29.89%);经停药和对症处理后转归良好。结论医药护应该高度重视抗菌药物引起的药物热,加强药物不良反应的监测,提高合理用药水平。Objective To explore the clinical manifestations,mechanism and general characteristics of drug fever induced by antimicrobial,and to prove reference for clinical safe and rational drug use.Methods CNKI,wanfang and VIP were searched for case reports between 1980 and 2019 on drug fever induced by antimicrobial by key words for analysis.Results A total of 239 literatures were included(323 case reports),more in male patients,mostly at 18~44 years old(n=132,40.87%).The primary diseases were mainly respiratory diseases(n=153,38.25%).Cephalosporin is the main drug causing drug fever(n=67,20.74%).Drug fever mostly appeared within 2~7 days(n=110,34.06%),and high fever was the main type(n=187,57.90%).Systemic involvement is the most common of the accompanying clinical symptoms(n=104,29.89%).Good outcome was achieved after drug withdrawal and symptomatic treatment.Conclusion The clinical workers should pay attention to drug fever induced by antimicrobial,strengthen the monitoring of ADR and improve the level of clinical rational drug use.

关 键 词：抗菌药物 药物热 药物不良反应 

分 类 号：R969[医药卫生—药理学] G353.1[医药卫生—药学]