Mitochondrial Dysfunction and Age-related Oocyte Quality  

作　　者：Han Li Ri-Cheng Chian 

机构地区：[1]Center for Reproductive Medicine,the 10th People’s Hospital of Tongjin University,Shanghai 200072,China [2]Department of Obstetrics and Gynecology,McGill University,Montreal,Canada

出　　处：《Reproductive and Developmental Medicine》2017年第1期45-54,共10页生殖与发育医学（英文版）

基　　金：supported by funding(to China RC)from the Ministry of Science and Technology of China(grants 2017YFC1001601).

摘　　要：Fertility disorders have become a growing problem worldwide. It is well known that female fertility decreases with age, previous studies suggested that the age-related decline in female fertility potential was largely due to decrease in oocyte quality and mitochondrial dysfunction. Mitochondria play a crucial role during the process of oocyte maturation. Mitochondrial genetic, numerical and structural defects occur in oocyte aging process, mitochondrial abnormalities are believed to contribute to age-related infertility. Improvement of the mitochondrial function can lead to better fertility outcomes, and application of mitochondria replacement strategy or mitochondrial transfer to age-related infertility will be possible in the future. This review paper, we are trying to discuss current understanding about age-related changes in oocyte quality and mitochondrial dysfunction.

关 键 词：Mitochondrial Dysfunction Oocyte Quality Therapeutic Strategies 

分 类 号：R714.8[医药卫生—妇产科学]