BMI与IVF/ICSI-ET术后自然流产胚胎染色体核型异常的关系  

Relationship between BMI and Embryo Chromosomal Karyotype Abnormality of Spontaneous Abortion after IVF/ICSI-ET

作　　者：吴军[1] 崔云静[1] 郭飞波 杨艳华[1] WU Jun;CUI Yunjing;GUO Feibo(Tianmen First People's Hospital of Hubei Province, Hubei Tianmen 431700, China)

机构地区：[1]湖北省天门市第一人民医院妇产科,湖北天门431700

出　　处：《河北医学》2021年第8期1279-1284,共6页Hebei Medicine

基　　金：湖北省卫生健康委员会科研项目,(编号:WJ2019M113)。

摘　　要：目的:检测体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)术后自然流产患者胚胎染色体核型异常的情况,并探讨体质量指数(BMI)与IVF/ICSI-ET术后自然流产胚胎染色体核型异常的关系。方法:回顾性分析2018年1月至2020年7月期间在天门市第一人民医院妇产科就诊的280例IVF/ICSI-ET术后自然流产患者,其中96例胚胎染色体核型正常患者(正常核型组),184例胚胎染色体核型异常患者(异常核型组)。对患者一般资料进行分析;分析IVF/ICSI-ET术后自然流产患者胚胎染色体核型的情况;分析患者BMI、流产年龄、流产次数与IVF/ICSI-ET术后自然流产胚胎染色体核型异常的关系;Logistic回归分析影响IVF/ICSI-ET术后自然流产患者胚胎染色体核型异常的因素。结果:两组不孕年限、不孕原因、不孕类型、助孕方式、促性腺激素(Gn)用量、Gn使用天数、基础卵泡刺激素(FSH)、获卵数、移植日内膜厚度、移植胚胎数目、移植优质胚胎数目比较,差异均无统计学意义(P>0.05);IVF/ICSI-ET术后自然流产患者正常核型组的比例为34.29%,异常核型组的比例为65.71%,其中异常核型组中以非整倍体为主,比例为41.07%;BMI值<21.4kg/m^(2)或>24.2kg/m^(2) IVF/ICSI-ET术后自然流产患者的异常核型比例显著高于BMI值21.4 kg/m^(2)~24.2 kg/m^(2)的患者(P<0.05);流产年龄≥36岁IVF/ICSI-ET术后自然流产患者的异常核型比例显著高于流产年龄<36岁的患者(P<0.05);流产次数>2次IVF/ICSI-ET术后自然流产患者的异常核型比例显著高于流产次数≤2次的患者(P<0.05);BMI是影响IVF/ICSI-ET术后自然流产患者出现胚胎染色体核型异常的独立危险因素(P<0.05)。结论:IVF/ICSI-ET术后自然流产患者以胚胎染色体异常核型为主,且患者的BMI与胚胎染色体核型异常有关。Objective:To detect the embryo chromosomal karyotype abnormality of patients with spontaneous abortion after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET),and to explore the relationship between body mass index(BMI)and embryo chromosomal karyotype abnormality of patients with spontaneous abortion after IVF/ICSI-ET.Methods:280 cases of patients with spontaneous abortion after IVF/ICSI-ET from January 2018 to July 2020 in department of obstetrics and gynecology,Tianmen first people's hospital were analyzed retrospectively,including 96 cases of embryonic chromosome normal karyotype patients(normal karyotype group)and 184 cases of embryonic chromosome abnormal karyotype patients(abnormal karyotype group).General data were analyzed;embryo chromosomal karyotype abnormality of patients with spontaneous abortion after IVF/ICSI-ET was analyzed;and the relationships between BMI,abortion age,abortion times and embryo chromosomal karyotype abnormality of patients with spontaneous abortion after IVF/ICSI-ET was analyzed;Logistic regression analysis of the factors influencing the embryonic chromosome abnormal karyotype in patients with spontaneous abortion after IVF/ICSI-ET.Results:There was no significant difference between the two groups in infertility duration,causes of infertility,type of infertility,mode of pregnancy aid,dosage of gonadotropins(GN),days of GN use,basic follicle-stimulating hormone(FSH),number of oocytes obtained,thickness of endometrium on the day of transplantation,number of embryos transferred and number of high-quality embryos transferred(P>0.05);the proportions of normal karyotype group and abnormal karyotype group were 34.29%and 65.71%respectively,and aneuploidy was the main karyotype in abnormal karyotype group(41.07%);the percentage of abnormal karyotypes in patients with spontaneous abortion after IVF/ICSI-ET whose BMI<21.4 kg/m^(2) or>24.2 kg/m^(2) was significantly higher than that in patients whose BMI of 21.4 kg/m^(2)~24.2 kg/m^(2)(P<0.05);the percentage

关 键 词：体外受精/卵泡浆内单精子注射受精-胚胎移植 自然流产 胚胎染色体核型异常 体质量指数 

分 类 号：R71[医药卫生—妇产科学]