探讨高流量湿化氧疗对老年肺炎患者临床疗效及炎症因子IL-8 IL-6的影响  

An Investigation of the Effect of High-Flow Humidified Oxygen Therapy on the Clinical Efficacy and the Expression of IL-8 and IL-6 in Elderly Patients with Pneumonia

作　　者：王国玉[1] 曲忠慧 李伟[1] 巴春贺[1] 王璐[1] 王浩宇[1] WANG Guoyu;QU Zhonghui;LI Wei(The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China)

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《河北医学》2021年第8期1321-1325,共5页Hebei Medicine

基　　金：河北省承德市科学技术局资助项目,(编号:201606A028)。

摘　　要：目的:探讨高流量湿化氧疗对老年肺炎患者临床疗效及炎症因子IL-8、IL-6的影响。方法:选取承德医学院附属医院老年病科2017年1月至2019年8月住院治疗的老年肺炎患者80例,随机分为研究组和对照组,各40例,两组都给予止咳、祛痰、抗炎等治疗措施,研究组应用气道高流量湿化氧疗,对照组采用传统鼻导管或吸氧面罩方法,比较治疗前后患者临床表现、心率(HR)、呼吸频率、血氧饱和度(SpO_(2))及IL-6、IL-8的变化。结果:治疗前,两组患者IL-6、IL-8指标差异无统计学意义(P>0.05);临床应用高流量湿化氧疗后,体温下降时间、痰液性状粘稠度变化时间、肺部啰音减少消失时间较对照组明显缩短,心率、呼吸频率明显低于对照组,SpO2明显高于对照组(P<0.05),血清IL-6、IL-8下降程度均高于对照组,差异比较,具有显著的统计学意义(P<0.05)。结论:应用高流量湿化氧疗能显著改善临床疗效,提高氧合,降低炎症因子IL-6、IL-8的表达水平。Objective:To investigate the effect of high-flow humidified oxygen therapy on the clinical efficacy and the expression of IL-8 and IL-6 in elderly patients with pneumonia.Methods:80 elderly patients with pneumonia admitted to our hospital from January 2017 to August 2019 were randomly divided into two groups,40 cases in each group.Both groups were administered antitussive,expectorant,anti-inflammatory and other treatment measures.40 patients of the control group were given traditional artificial airway humidification method,while 40 patients of the study group were given high flow humidified oxygen therapy.The clinical symptoms,heart rate,suction frequency,SPO2,serum IL-6 and serum IL-8 levels of the two groups were observed and compared before and after treatment.Results:Before treatment,there were no significant difference in serum IL-6 and IL-8 between the two groups(P>0.05).After clinical application of high-flow humidified oxygen therapy,Hypothermic time,time of change of character and viscosity from sputum,decreased or disappearance time of lung rales in the study group were significantly shorter than those of the control group;heart rate and aspiration frequency were lower and SPO_(2) was higher than those of the control group(P<0.05).The decrease of serum IL-6 and IL-8 in the study group were significantly lower than those in the control group.(P<0.05).Conclusion:Application of high flow humidified oxygen therapy can significantly improve the clinical efficacy,increase oxygenation,reduce the expression of inflammatory factors IL-6,IL-8.

关 键 词：肺炎 老年人 血清IL-8 高流量湿化氧疗 

分 类 号：R47[医药卫生—护理学]