化疗导致右心室损伤研究进展  

Research progress in right ventricular damage caused by chemotherapy

作　　者：李丽丽[1] 王阿倩 陈雅玲 贾孟菲 曹云山[2] LI Lili;WANG Aqian;CHEN Yaling;JIA Mengfei;CAO Yunshan(The First Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou Gansu 730000;Department of Cardiology,Gansu Provincial Hospital,Lanzhou Gansu 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院心内科,甘肃兰州730000

出　　处：《实用心电学杂志》2021年第4期235-241,共7页Journal of Practical Electrocardiology

摘　　要：化疗药物可以引起心血管并发症,以往研究的焦点是左心室,而忽视了右心室。近年来的研究表明,化疗药物引起的心脏损害往往同时累及左右心室,因此,右心室重构不应被忽视。蒽环类药物和曲妥珠单抗等可显著影响右心室的结构与功能。化疗药物导致右心室重构的机制尚不完全清楚,可能与化疗药物对心肌的直接损伤、氧化应激、内皮功能障碍以及对肺循环的损伤有关。本文就化疗药物对右心室重构的影响进行综述。Chemotherapeutic drugs could cause cardiovascular complications.Previous studies focused on the left ventricle,ignoring the right ventricle.Recent studies have shown that chemotherapeutic drug-induced heart injury usually synchronously involves both the right ventricle and the left ventricle,and therefore right ventricular remodeling should not be ignored.Anthracyclines,trastuzumab,etc.could significantly affect the structure and function of the right ventricle.The mechanism of right ventricular remodeling caused by chemotherapeutic drugs is not completely clear at present.It may be related to the direct myocardial injury,oxidative stress,endothelial dysfunction and pulmonary circulation damage caused by chemotherapeutic drugs.This article reviews on the effects of chemotherapeutic drugs on right ventricular remodeling.

关 键 词：化疗药物 右心室 心室重构 肺动脉高压 

分 类 号：R544.16[医药卫生—心血管疾病]