S100A12、ABI及non-HDL-C在冠状动脉粥样硬化心脏病中的表达及对预后的预测价值  

Expressions of S100A12,ABI and Non-HDL-C and Their Values in Prediction of Prognoses of Patients with Coronary Atherosclerotic Heart Disease

作　　者：倪志强 金红艳[2] 杨国康[2] 李涵 谢彬[2] NI Zhi-qiang;JIN Hong-yan;YANG Guo-kang;LI Han;XIE bin(School of Medicine,Wuhan University of Science and Technology,Wuhan 430000,China;Department of Vasculocardiology,Hanyang Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430000,China)

机构地区：[1]武汉科技大学医学院,武汉430000 [2]武汉科技大学附属汉阳医院心血管内科,武汉430000

出　　处：《解放军医药杂志》2021年第8期66-69,91,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：湖北省卫健委科研项目资助(WJ2019F032)。

摘　　要：目的探讨S100A12、踝臂指数(ABI)及非高密度脂蛋白胆固醇(non-HDL-C)在冠状动脉粥样硬化心脏病(CHD)中的表达及对其预后的预测价值。方法选取2014年1月—2015年5月本院接收的90例CHD为观察组,选取同期在本院体检结果正常且临床资料完整者62例为对照组。比较2组S100A12、ABI、non-HDL-C水平,分析S100A12、ABI、non-HDL-C及三者联合检测对CHD预后不良的预测价值及影响CHD预后不良的危险因素。结果与对照组比较,观察组S100A12、non-HDL-C水平升高,ABI水平降低,差异有统计学意义(P<0.01)。S100A12、ABI、non-HDL-C异常是影响CHD预后不良的独立危险因素(P<0.01)。S100A12、ABI、non-HDL-C及三者联合检测的曲线下面积分别为0.946、0.068、0.051、0.990,各指标曲线下面积以联合检测最大。结论S100A12、ABI及non-HDL-C水平在CHD患者中呈异常表达状态,S100A12、ABI及non-HDL-C水平异常是影响CHD预后不良的独立危险因素,三指标联合检测对评估该类患者的病情变化及预后情况有重要价值。Objective To explore expressions of S100A12,ankle brachial index(ABI)and non-high density lipoprotein cholesterol(non-HDL-C)and their values in prediction of prognoses of patients with coronary atherosclerotic heart disease(CAHD).Methods A total of 90 patients with CAHD admitted between January 2014 and May 2015 were selected as observation group,and other 62 healthy people with normal results of physical examinations and complete clinical data at the same period were selected as control group.Levels of S100A12,ABI and non-HDL-C were compared between two groups.Values of S100A12,ABI,non-HDL-C and combination of the three indexes in prediction of poor prognoses and risk factors affecting poor prognoses of patients with CAHD were analyzed.Results In observation group,levels of S100A12 and non-HDL-C were significantly higher than those in control group,while ABI value was significantly lower than that in control group(P<0.01).Abnormal levels of S100A12,ABI and non-HDL-C were independent risk factors affecting poor prognoses of patients with CAHD(P<0.01).Areas under the curve(AUC)of S100A12,ABI,non-HDL-C and combination of the three indexes were 0.946,0.068,0.051 and 0.990 respectively,and AUC of combination of the three indexes was the largest.Conclusion Levels of S100A12,ABI and non-HDL-C are abnormally expressed in patients with CAHD.Abnormal levels of S100A12,ABI and non-HDL-C are independent risk factors affecting poor prognoses of patients with CAHD.Combined detection of the three indexes has important predictive value in assessing changes of patients'conditions and prognoses.

关 键 词：冠状动脉粥样硬化心脏病 S100A12 踝臂指数 非高密度脂蛋白胆固醇 预测 危险因素 预后 

分 类 号：R541.4[医药卫生—心血管疾病]