芪术胶囊联合穴位贴敷对糖尿病肾病Ⅲ-Ⅳ期患者血脂、肾功能和血清TGF-β1、CTGF水平的影响  

Effect of Qizhu Capsule Combined with Acupoint Application on Blood Lipid,Renal Function and Serum TGF-β1,CTGF Levels in Patients with Diabetic Nephropathy StageⅢ-Ⅳ

作　　者：康慧霞 邢建月[1] 郭二华[1] 邢大庆[1] 郭晓霏[2] KANG Hui-xia;XING Jian-yue;GUO Er-hua;XING Da-qing;GUO Xiao-fei(Second Department of Nephrology,Shanxi Hospital of Traditional Chinese Medicine,Taiyuan,Shanxi,030012,China;Department of Endocrine,Shanxi Hospital of Traditional Chinese Medicine,Taiyuan,Shanxi,030012,China)

机构地区：[1]山西省中医院肾病二科,山西太原030012 [2]山西省中医院内分泌科,山西太原030012

出　　处：《现代生物医学进展》2021年第15期2939-2942,共4页Progress in Modern Biomedicine

基　　金：山西省科技厅科技攻关计划(141078)。

摘　　要：目的:观察芪术胶囊联合穴位贴敷对糖尿病肾病(DN)Ⅲ-Ⅳ期患者血脂、肾功能和血清转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)水平的影响。方法:选择2018年3月~2020年8月期间我院收治的DN患者90例,将患者按随机数字表法分为对照组(n=45)和研究组(n=45),对照组予以常规西医治疗,研究组在对照组的基础上给予芪术胶囊联合穴位贴敷治疗,均治疗4周。比较两组患者的疗效、中医证候积分、血脂、肾功能和血清TGF-β1、CTGF水平。结果:治疗4周后,研究组的临床总有效率88.89%(40/45)高于对照组68.89%(31/45)(P<0.05)。治疗4周后,研究组中医证候积分、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、血肌酐(Scr)、血尿素氮(BUN)、TGF-β1、CTGF、尿白蛋白排泄率(UAER)低于对照组(P<0.05),高密度脂蛋白(HDL)高于对照组(P<0.05)。结论:芪术胶囊联合穴位贴敷治疗DNⅢ-Ⅳ期患者,可有效改善患者血脂及肾功能,促进症状缓解,降低血清TGF-β1、CTGF水平。Objective:To observe the effect of Qizhu capsule combined with Acupoint Application on blood lipid,renal function and serum levels of transforming growth factor-β1(TGF-β1)and connective tissue growth factor(CTGF)in patients with diabetic nephropathy(DN)at stageⅢ-Ⅳ.Methods:90 patients with DN in our hospital from March 2018 to August 2020 were selected,and they were randomly divided into control group(n=45)and study group(n=45).The control group was treated with conventional western medicine,and the study group was treated with Qishu capsule combined with Acupoint Application on the basis of the control group,with 4 weeks of treatment.The curative effect,TCM syndrome score,blood lipid,renal function,serum TGF-β1 and CTGF levels were compared between the two groups.Results:After 4 weeks of treatment,the total effective rate of the study group was 88.89%(40/45),which was higher than 68.89%(31/45)of the control group(P<0.05).After 4 weeks of treatment,the TCM syndrome score,total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),serum creatinine(SCR),blood urea nitrogen(BUN),TGF-β1,CTGF and urinary albumin excretion rate(UAER)of the study group were lower than those of the control group(P<0.05),and the high density lipoprotein(HDL)of the study group was higher than that of the control group(P<0.05).Conclusion:Qizhu capsule combined with acupoint application can effectively improve the blood lipid and renal function of patients with DN stageⅢ-Ⅳ,promote the remission of symptoms,and reduce the levels of serum TGF-β1 and CTGF.

关 键 词：芪术胶囊 穴位贴敷 糖尿病肾病 Ⅲ-Ⅳ期 血脂 肾功能 TGF-β1 CTGF 

分 类 号：R587.2[医药卫生—内分泌] R243[医药卫生—内科学]