多囊卵巢综合征患者血清IMA、HIF1α、Vaspin、IGF-1水平与性激素、糖脂代谢及胰岛素抵抗的关系研究  

Relationship between Serum IMA, HIF1α, Vaspin, IGF-1 Levels and Sex Hormone, Glucose and Lipid Metabolism, Insulin Resistance in Patients with Lycystic Ovary Syndrome

作　　者：欧英霞 杨盼 龙玲 何小丽 黎丽[1] 于秀云 OU Ying-xia;YANG Pan;LONG Ling;HE Xiao-li;LI Li;YU Xiu-yun(Department of Gynaecology,Changsha Maternal and Child Health Hospital Affiliated to Hunan Normal University,Changsha,Hunan,410000,China;Reproductive Center,Changsha Maternal and Child Health Hospital Affiliated to Hunan Normal University,Changsha,Hunan,410000,China)

机构地区：[1]湖南师范大学附属长沙市妇幼保健院妇科,湖南长沙410000 [2]湖南师范大学附属长沙市妇幼保健院生殖中心,湖南长沙410000

出　　处：《现代生物医学进展》2021年第14期2773-2777,共5页Progress in Modern Biomedicine

基　　金：湖南省卫健委科研计划项目(20200208)。

摘　　要：目的:探讨多囊卵巢综合征(PCOS)患者血清缺血修饰白蛋白(IMA)、缺氧诱导因子1α(HIF1α)、内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)、胰岛素样生长因子-1(IGF-1)水平与性激素、糖脂代谢及胰岛素抵抗的相关性。方法:选择2017年1月至2019年12月我院收治的268例PCOS患者(PCOS组),根据体质量指数(BMI)将PCOS患者分为超重/肥胖组(BMI≥24kg/m2,161例)和正常体重组(18.5 kg/m2≤BMI<24 kg/m2,107例),另选择135例于妇科门诊体检的健康女性志愿者为对照组。检测血清IMA、HIF1α、Vaspin、IGF-1水平以及性激素、糖脂代谢、胰岛素抵抗指标,Pearson相关性分析其相关性。结果:PCOS组血清IMA、HIF1α、Vaspin、IGF-1、睾酮(T)、促黄体生成素(LH)、促卵泡激素(FSH)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、餐后2小时血糖(2h PG)、空腹胰岛素(FINS)水平,胰岛素抵抗指数(HOMA-IR)均高于对照组(P<0.001)。PCOS患者超重/肥胖组血清IMA、HIF1α、Vaspin、IGF-1、T、TC、LDL-C、FPG、FINS、2h PG水平,HOMA-IR均高于正常体重组(P<0.001)。PCOS患者血清IMA、HIF1α水平与T、HOMA-IR呈正相关(P<0.05),血清Vaspin、IGF-1水平与TC、LDL-C、FPG、FINS、2h PG、HOMA-IR呈正相关(P<0.05)。结论:PCOS患者血清IMA、HIF-1α、Vaspin、IGF-1水平均升高,IMA、HIF-1α、Vaspin、IGF-1均与PCOS胰岛素抵抗有关。Objective:To investigate the correlation of serum ischemia modified albumin (IMA),hypoxia inducible factor-1α(HIF1α),visceral fat specific serine protease inhibitor (Vaspin),insulin-like growth factor-1 (IGF-1) levels with sex hormones,glucose and lipid metabolism and insulin resistance in patients with polycystic ovary syndrome (PCOS).Methods:268 PCOS patients (PCOS group) were selected from January 2017 to December 2019,and they were divided into overweight/obesity group (BMI≥24 kg/m2,161cases) and normal weight group (18.5 kg/m2≤BMI<24kg/m2,107 cases) according to body mass index (BMI).Another 135 healthy female volunteers in gynecological clinic were selected as control group.The serum levels of IMA,HIF1α,Vaspin,IGF-1,sex hormone,glucose and lipid metabolism,insulin resistance and Pearson correlation analysis were performed.Results:The levels of serum IMA,HIF1α,Vaspin,IGF-1,testosterone (T),luteinizing hormone (LH),follicle stimulating hormone (FSH),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),fasting blood glucose (FPG),2 hour postprandial blood glucose (2h PG),fasting islet insulin(FINS) and insulin resistance index (HOMA-IR) in PCOS group were higher than those in control group (P<0.001).The levels of IMA,HIF1α,Vaspin,IGF-1,T,TC,LDL-C,FPG,FINS,2h PG and HOMA-IR in overweight/obesity group were higher than those in normal weight group (P<0.001).The levels of IMA and HIF1αwere positively correlated with T and HOMA-IR (P<0.05).The levels of Vaspin and IGF-1 were positively correlated with TC,LDL-C,FPG,FINS,2h PG and HOMA-IR (P<0.05).Conclusion:The serum levels of IMA,HIF1α,Vaspin and IGF-1 are increased in PCOS patients.IMA,HIF1α,Vaspin and IGF-1 are related to insulin resistance in PCOS.

关 键 词：多囊卵巢综合征 IMA HIF1Α VASPIN IGF-1 糖脂代谢 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]