血府逐瘀胶囊联合屈螺酮炔雌醇片预防宫腔镜术后子宫内膜息肉复发  

Prevention of recurrence after hysteroscopic endometrial polyp excision by Xuefuzhuyu capsule combined with drospirenone ethinylestradiol tablets

作　　者：李晓培[1] 王伟伟[1] 何青青[1] LI Xiaopei;WANG Weiwei;HE Qingqing(The Second Affiliated Hospital of Luohe Medical College, Henan Province, 462000)

机构地区：[1]河南省漯河医学高等专科学校第二附属医院,462000

出　　处：《中国计划生育学杂志》2021年第7期1348-1351,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨宫腔镜术后应用血府逐瘀胶囊联合屈螺酮炔雌醇片对子宫内膜息肉(EP)复发的预防作用。方法:选择2016年2月-2018年10月本院行宫腔镜镜直视下EP切除(TCRP)治疗的EP患者,随机数字原则分为观察组(96例)与对照组(94例),观察组TCRP术后给予血府逐瘀胶囊联合屈螺酮炔雌醇片,对照组TCRP术后给予屈螺酮炔雌醇片。比较两组术后子宫内膜厚度、月经量、并发症、EP复发等情况。结果:两组术后6、12、18个月子宫内膜厚度及PBAC评分均小于术前,且观察组小于对照组(P均<0.05);两组胃肠道反应及不规则阴道流血发生率无差异(P>0.05)。EP复发率,术后6个月两组(1.1%、0.0%)无差异(P>0.05),术后12、18个月观察组(3.1%、7.3%)低于对照组(11.7%、19.2%)(P<0.05);两组最大息肉平均直径≥2.0cm患者术后6个月无差异(P>0.05),术后12、18个月观察组(2.0%、4.1%)低于对照组(15.4%、23.1%)(P<0.05),直径<2.0cm患者术后6、12、18个月无差异(P>0.05);两组息肉数目≥3个患者术后6个月无差异(P>0.05),术后12、18个月观察组(4.3%、4.3%)低于对照组(19.1%、23.8%)(P<0.05),两组息肉数目<3个患者术后6、12、18个月均无差异(P>0.05)。结论:血府逐瘀胶囊联合屈螺酮炔雌醇片对TCRP术后预防EP复发的效果优于单纯屈螺酮炔雌醇片,尤其是对于息肉较大和数目较多的患者。Objective:To investigate the effect of Xuefuzhuyu capsule combined with drospirenone ethinylestradiol tablets for preventing endometrial polyp(EP)recurrence of women after hysteroscopic endometrial polyp excision.Methods:The women with EP after hysteroscopy endometrial polyps excision were selected as the study objects from February 2016 to October 2018.These women were divided into observation group and control group according to the principle of random number.The women in the observation group were treated with Xuefuzhuyu capsule combined with drospirenone ethinylestradiol tablets,and the women in the control group were treated with drospirenone ethinylestradiol tablet.The endometrial thickness,menstrual volume,complications rate,and EP recurrence rate in 6 months,12 months and 18 months of the women after operation were compared between the two groups.Results:The endometrial thickness and PBAC score in 6,12 and 18 months after operation of the women in the two groups had decreased significantly,and which of the women in the observation group were significant lower than those of the women in the control group(all P<0.05).There were no significant differences in the incidences of gastrointestinal reactions and irregular vaginal bleeding of the women between the two groups(P>0.05).There was no significant difference in the recurrence rate of EP(1.1%vs.0.0%)of the women in 6 months after operation between the two groups(P>0.05),but which(3.1%and 7.3%)of the women in the observation group in 12 and 18 months after operation were significant lower than those(11.7%and 19.2%)of the women in the control group(P<0.05).There was no significant difference in the rate of the women with the average diameter of maximum polyps≥2.0cm in 6 months after surgery between the two groups(P>0.05),but which(2.0%and 4.1%)of the women in the observation group in 12 and 18 months after operation were significant lower than those(15.4%and 23.1%)of the women in the control group(P<0.05).There was no significant difference in the rate of

关 键 词：子宫内膜息肉 宫腔镜术后 血府逐瘀胶囊 屈螺酮炔雌醇 复发 

分 类 号：R71[医药卫生—妇产科学]