2014-2020年天津某院真菌血症病原菌分布及耐药性分析  

Analysis for distribution and drug resistance of fungemia pathogen from 2014 to 2020 in a Tianjin hospital

作　　者：李妍淳[1] 田彬[1] 岳娜[1] 胡志东[1] LI Yanchun;TIAN Bin;YUE Na;HU Zhidong(Department of Clinical Laboratory,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院医学检验科,天津300052

出　　处：《检验医学》2021年第8期800-804,共5页Laboratory Medicine

基　　金：天津市卫生局科技基金项目(2013KZ125)。

摘　　要：目的分析2014—2020年天津医科大学总医院真菌血症病原菌的分布和耐药性,为真菌血症临床诊断和抗菌药物使用提供依据。方法对2014—2020年天津医科大学总医院真菌血症患者的临床资料进行回顾性分析,应用WHONET 5.6软件对血培养分离的酵母样真菌的分布和药物敏感性试验结果进行统计分析。结果7年间共分离出酵母样真菌401株,分离率较高的为近平滑念珠菌(199株,49.63%)、白念珠菌(62株,15.46%)、热带念珠菌(37株,9.23%)和光滑念珠菌(37株,9.23%)。真菌血症患者以男性(63.34%)居多,≥65岁老年人占56.11%。酵母样真菌对5-氟胞嘧啶和两性霉素B敏感性较高,不同菌种对唑类药物的耐药性不同。结论近平滑念珠菌为天津医科大学总医院真菌血症患者分离率最高的真菌。光滑念珠菌、热带念珠菌、红酵母属对唑类药物的敏感性相对较低。了解医院真菌血症病原菌的分布和耐药情况,对真菌血症患者的诊治和预后评估有重要意义。Objective To analyze the distribution and drug resistance of fungemia pathogen from 2014 to 2020 in Tianjin Medical University General Hospital,and to provide a reference for clinical diagnosis and antibiotic usage of fungemia.Methods The clinical data of fungemia patients from 2014 to 2020 were analyzed retrospectively.The distribution and antimicrobial sensitivity results were analyzed statistically by WHONET 5.6 software.Results A total of 401 isolates of yeast-like fungi were isolated from blood culture during the 7 years,and the main isolates were Candida parapsilosis(199 isolates,49.63%),Candida albicans(62 isolates,15.46%),Candida tropicalis(37 isolates,9.23%)and Candida glabrata(37 isolates,9.23%).The majority of fungemia patients were males(63.34%)and were aged≥65-year-old(56.11%).All the isolates were highly sensitive to 5-flucytosine and amphotericin B,and different genera presented various degrees of resistance to azoles.Conclusions Candida parapsilosis is the most common pathogen of fungemia in Tianjin Medical University General Hospital.The sensitivity rates of Candida glabrata,Candida tropicalis and Rhodotorula to azoles are relatively low.Analyzing the distribution and drug resistance of fungemia pathogen is of significance in the diagnosis,treatment and prognosis of patients with fungemia.

关 键 词：真菌血症 血培养 酵母样真菌 耐药 

分 类 号：R446.1[医药卫生—诊断学]