某三级中医医院细菌耐药与抗菌药物使用情况相关性分析  

Correlation analysis of drug resistance and antibiotic usage in a Grade 3 traditional Chinese medicine hospital

作　　者：辛冉 高翔[1] 安海英[1] 辛广勤[2] 戴伟利[1] 宫晶书[1] XIN Ran;GAO Xiang;AN Haiying;XIN Guangqin;DAI Weili;GONG Jingshu(Beijing Hospital of Traditional Chinese Medicine,Beijing 100010,China;Dezhou University,Dezhou 253023,Shandong,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]德州学院,山东德州253023

出　　处：《检验医学》2021年第8期809-813,共5页Laboratory Medicine

摘　　要：目的探讨某三级中医医院细菌耐药与抗菌药物使用情况的相关性。方法分析首都医科大学附属北京中医医院2013—2020年常见多重耐药菌(MDRO)检出情况与抗菌药物用药频度,采用Pearson相关分析或Spearman相关分析评价MDRO检出率与抗菌药物用药频度的相关性。结果2013—2020年,首都医科大学附属中医医院碳青霉烯类耐药肠杆菌科细菌(CRE)的检出率呈上升趋势;CRE的检出率与碳青霉烯类抗菌药物的用药频度呈正相关(P=0.0225),耐万古霉素肠球菌的检出率与糖肽类(P=0.0012)、大环内脂类(P=0.0063)、青霉素类(P=0.0081)抗菌药物的用药频度呈正相关(P=0.0488)。结论MDRO的检出率与抗菌药物使用频度存在一定的相关性,科学、合理地使用抗菌药物对MDRO的防控十分重要。Objective To investigate the correlation of drug resistance and antibiotic usage in a Grade 3 traditional Chinese medicine hospital.Methods The determination status and antibiotic usage data from 2013 to 2020 were collected,and the correlation between the determination rate of multiple drug resistant organisms(MDRO)and antibiotic defined daily doses was analyzed by Pearson or Spearman correlation analysis.Results In 2013-2020,the determination rate of methicillin-resistant Staphylococcus aureus(MRSA)showed an increased trend.The determination rate of CRE showed a positive correlation with the defined daily dose of carbapenems(P=0.0225),and the determination rate of vancomycin-resistant Enterococcus showed positive correlations with the defined daily doses of polypeptides(P=0.0012),macrolides(P=0.0063)and penicillin(P=0.0081).Conclusions The determination rate of MDRO is correlated with the antibiotic defined daily dose,and it is important for MDRO prevention and control to use antibiotic reasonably and scientifically.

关 键 词：多重耐药 抗菌药物 用药频度 中医医院 

分 类 号：R446.1[医药卫生—诊断学]