血液相容性改善策略与研究进展  

A Review on Improvement and Devolvement of Blood Compatibility

作　　者：缪翠娥 李鹏飞[1] 王丽娟[1] 袁江[1] 沈健[1,2] MIAO Cui-e;LI Peng-fei;WANG Li-juan;YUAN Jiang;SHEN Jian(National and Local Joint Engineering Research Center of Biomedical Functional Materials,Nanjing Normal University,Nanjing 210023,China;Jiangsu Engineering Research Center of Interfacial Chemistry,Nanjing University,Nanjing 210023,China)

机构地区：[1]生物医药功能材料国家地方联合工程研究中心,南京师范大学,南京210023 [2]江苏省界面化学工程技术研究中心,南京大学,南京210023

出　　处：《高分子通报》2021年第7期1-12,共12页Polymer Bulletin

基　　金：生物医药功能材料国家地方联合创新服务平台建设(2014103SB90102);江苏省教育厅基金(19KJA310001)。

摘　　要：血液接触类医疗器械已被广泛应用于临床诊治居人类病死率首位的心血管病。血液相容性是血液接触类生物材料最为重要的评价指标。改善和提高血液相容性仍是血液接触类生物材料研发的主要任务和中心内容,对经济建设、社会进步和人类健康意义重大。本文系统综述了血液相容性研究的理论基础,重点阐述了血液相容性的改善策略(生物仿生、生物惰性和生物活性策略)和血液接触类生物材料的制备技术,扼要展望了血液相容性研究的发展前景。Blood-contacting devices have been widely used in the clinical diagnosis and treatment of cardiovascular disease,which has the highest mortality rate in human beings.Blood compatibility is the most important evaluation index for blood-contacting materials.Improvement of blood compatibility is always the main task and central content for blood-contacting biomaterials,which is of great significance to economic development,social progress and human health.Herein,the theoretical basis of blood compatibility are systematically reviewed.The improvement strategies(including biomimic,bioinert,and bioactive strategies)and composite techniques of blood compatible materials are emphatically described.In the summary,the perspectives of blood compatibility research are prospected.

关 键 词：血液相容性 血液接触材料 综述 

分 类 号：R318.08[医药卫生—生物医学工程]