孕妇血清维生素D和维生素E水平与妊娠期高血压疾病发生的相关性  

Correlations between vitamin D,vitamin E levels of pregnant women and onset of hypertensive disorder complicating pregnancy

作　　者：吕祺[1] 阴春霞[1] 周硕 谭育松[1] 袁卓[1] LYU Qi;YIN Chun-Xia;ZHOU Shuo(Changchun Municipal Obstetrics and Gynecology Hospital,Changchun,Jilin 130042,China)

机构地区：[1]长春市妇产医院,吉林长春130042

出　　处：《中国妇幼保健》2021年第16期3662-3665,共4页Maternal and Child Health Care of China

基　　金：吉林省卫生与健康技术创新项目(2018J005)。

摘　　要：目的检测孕妇血清维生素D、E水平,分析维生素D、E与妊娠期高血压疾病发生之间的关联性。方法选取2019年8月-2020年10月在长春市妇产医院进行产检并分娩,检测孕早期血清维生素D水平低的210例孕妇,随机分成对照组(103例)和观察组(107例)。选取同期分娩的妊娠期高血压疾病孕妇118例和非妊娠期高血压疾病孕妇138例,孕期未给予任何干预。检测血清维生素D、E水平。观察组口服碳酸钙D3,对照组不予任何药物治疗。比较观察组和对照组血清维生素D水平,补充外源性维生素D后观察组和对照组妊娠分娩结局,妊娠期高血压疾病组和非妊娠期高血压疾病组孕早期血清维生素E水平。结果孕早期,观察组和对照组血清维生素D水平分别为(17.71±5.69)ng/ml和(15.62±4.54)ng/ml,差异无统计学意义(t=0.286,P>0.05);孕晚期,观察组和对照组血清维生素D水平分别为(26.17±5.82)ng/ml和(16.27±4.87)ng/ml,差异有统计学意义(t=2.182,P<0.05)。观察组子痫前期发生率、剖宫产率、胎儿生长受限发生率、胎儿窘迫发生率及早产发生率分别为11.21%、28.97%、1.87%、4.67%及2.80%,显著低于对照组的30.10%、56.31%、8.74%、15.53%及10.68%,差异均有统计学意义(χ^(2)=11.491,P=0.001;χ^(2)=16.063,P=0.000;χ^(2)=4.988,P=0.026;χ^(2)=6.879,P=0.009;χ^(2)=5.232,P=0.022)。妊娠期高血压疾病组和非妊娠期高血压疾病组血清维生素E水平分别为(15.605±3.980)mg/L和(9.229±2.035)mg/L,差异有统计学意义(t=1.210,P<0.05)。结论孕妇血清维生素D、E水平与妊娠期高血压疾病的发生明显相关。孕早期维生素D缺乏可以预测妊娠期高血压疾病,及时补充外源性维生素D可以有效降低妊娠期高血压疾病和相关并发症的发生;孕早期血清维生素E水平高的孕妇发生妊娠期高血压疾病的风险高,检测血清维生素E可以预测妊娠期高血压疾病。Objective To detect the levels of serum vitamin D and vitamin E in pregnant women,analyze the correlations between vitamin D,vitamin E levels of pregnant women and onset of hypertensive disorder complicating pregnancy.Methods From August 2019 to October 2020,210 early pregnant women with low levels of serum vitamin D treated in Changchun Municipal Obstetrics and Gynecology Hospital were selected and randomly divided into control group(103 cases) and observation group(107 cases),118 pregnant women with hypertensive disorder complicating pregnancy and 138 pregnant women without hypertensive disorder complicating pregnancy were selected,no intervention or treatment was applied during pregnancy. The levels of serum vitamin D and vitamin E were detected. The pregnant women in observation group were supplemented with exogenous calcium carbonate vitamin D3,and the pregnant women in control group were not given any drug. The levels of serum vitamin D in observation group and control group,the pregnancy outcomes after supplementation of exogenous vitamin D in observation group and control group,the levels of serum vitamin E in hypertensive disorder complicating pregnancy group and non-hypertensive disorder complicating pregnancy group were compared.Results In early pregnancy,the levels of serum vitamin D in observation group and control group were(17.71±5.69) ng/ml and(15.62±4.54) ng/ml,respectively,there was no statistically significant difference(t=0.286,P>0.05). In late pregnancy,the levels of serum vitamin D in observation group and control group were(26.17±5.82) ng/ml and(16.27±4.87) ng/ml,respectively,there was statistically significant difference(t=2.182,P<0.05). The incidence rate of preeclampsia,cesarean section rate,the incidence rates of fetal growth restriction,fetal distress,and premature delivery in observation group were 11.21%,28.97%,1.87%,4.67%,and 2.80%,respectively,which were statistically significantly lower than those in control group(30.10%,56.31%,8.74%,15.53%,and 10.68%,respectively)(χ^(2)=11.4

关 键 词：孕妇 维生素D 维生素E 妊娠结局 

分 类 号：R714.1[医药卫生—妇产科学]