更年期心律失常患者倍他乐克联合胺碘酮治疗的有效性分析  

Effectiveness of Betaloc and amiodarone in menopausal arrhythmia patients

作　　者：曾劲 文芳 邓建松[2] 卢洁 王秀萍 张书勤[2] ZENG Jin;WEN Fang;DENG Jian-Song(Department of Pharmacy,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430077,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院药剂科,湖北武汉430077 [2]华中科技大学同济医学院附属梨园医院公共卫生科,湖北武汉430077 [3]长江水利委员会长江医院内科,湖北武汉430011

出　　处：《中国妇幼保健》2021年第16期3841-3844,共4页Maternal and Child Health Care of China

基　　金：湖北省知识创新专项(自然科学基金)(2016CFB646)。

摘　　要：目的探讨倍他乐克联合胺碘酮治疗对更年期心律失常患者左心室射血分数水平的影响。方法选取2018年7月-2019年6月该院收治的更年期心律失常患者108例。依据药物治疗方案的不同分为对照组和研究组,给予对照组患者倍他乐克治疗,给予研究组患者联合胺碘酮治疗。临床治疗效果、心功能指标水平、两组患者血清中去甲肾上腺素(NE)、肾上腺素(E)浓度、血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)水平以及对比两组患者用药后的药物不良反应状况。结果研究组患者的临床治疗总有效率为83.6%,对照组治疗总有效率为63.2%,研究组疗效好于对照组(P<0.05);经治疗干预,研究组患者心功能指标水平均有所好转,研究组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)水平比对照组更低,左室射血分数(LVEF)、左室收缩压(LVPS)水平均比对照组更高(P<0.05);研究组患者恶心、心动过缓及静脉炎的总发生率为16.7%;治疗前两组患者血清中NE、E、PRA、 AngⅡ及ALD水平比较,差异均无统计学意义(P>0.05),治疗3个月后研究组患者血清中上述指标水平均优于对照组(P<0.05);对照组不良反应的总发生率为18.5%,两组差异无统计学意义(P>0.05)。结论在更年期心律失常患者的临床治疗中应用倍他乐克联合胺碘酮方案治疗效果显著,可显著提升患者左心室射血分数水平,减少左室收缩末期与舒张末期内径,提升左室收缩压,改善心肌血管内皮功能,应用效果满意,可考虑普及应用。Objective To investigate the effect of Betaloc and amiodarone on left ventricular ejection fraction in patients with menopausal arrhythmia.Methods A total of 108 patients with menopausal arrhythmia who were treated during this period from July 2018 to June 2019 were selected as the subjects of this study.According to different drug treatment schemes,they were divided into control group and study group.Patients in the control group were treated with Betaloc and patients in the study group were treated with amiodarone.Compare the clinical treatment effect,cardiac function index level,serum norepinephrine(NE),adrenaline(E) concentration,plasma renin(PRA),angiotensin Ⅱ(AngⅡ),aldosterone(ALD) levels and comparison of adverse drug reactions between the two groups.Results The total effective rate of clinical treatment in the study group was 83.6%,and the total effective rate in the control group was 63.2%.The effect of the study group was better than that of the control group(P<0.05).After treatment intervention,the levels of cardiac function indicators in the study group were all The improvement was that the levels of LVESD and LVEDD in the study group were lower than those in the control group,and the levels of LVEF and LVPS were higher than those in the control group(P<0.05).The total incidence of nausea,bradycardia,and phlebitis in the study group was 16.7%;There was no significant difference in the levels of NE,E,PRA,AngⅡ,and ALD in the serum of the two groups of patients before treatment(P>0.05),and the above-mentioned indicators in the serum of the study group were better than the control group after 3 months of treatment(P<0.05);The total incidence of adverse reactions in the control group was 18.5%,and the differences between the two groups were not comparable(P>0.05).Conclusion In the clinical treatment of menopausal arrhythmia patients,the application of Betaloc and amiodarone regimen has a significant effect,which can significantly increase the left ventricular ejection fraction,reduce the diameter of

关 键 词：倍他乐克 胺碘酮 更年期心律失常 左心室射血分数水平 

分 类 号：R453[医药卫生—治疗学]