嗜酸性粒细胞增多性皮炎29例临床分析  

Clinical analysis of 29 cases of eosinophilic dermatitis

作　　者：邵丽芳 田蓉 赵广 SHAO Li-fang;TIAN Rong;ZHAO Guang(Department of Dermatology,Air Force Medical Center,PLA,Beijing100142,China)

机构地区：[1]空军特色医学中心皮肤科,北京100142

出　　处：《中国当代医药》2021年第23期12-16,F0003,共6页China Modern Medicine

摘　　要：目的探讨嗜酸性粒细胞增多性皮炎的临床特点、实验室检查及治疗方法。方法回顾性分析2012年1月—2019年12月空军特色医学中心皮肤科住院的29例嗜酸性粒细胞增多性皮炎患者的临床资料。结果29例患者中,男女比例为3.1∶1,平均年龄(61.3±14.18)岁。28例患者皮疹泛发全身,主要表现为两种类型:一种为浸润性或肿胀性鲜红斑,占比41.4%;另一种为泛发性坚实的丘疹、结节,伴或不伴苔藓样改变及皮肤干燥脱屑,占比31.0%。实验室检查显示,除嗜酸性粒细胞明显增多外,85.2%的患者乳酸脱氢酶升高,63.0%的患者α-羟丁酸脱羧酶增高。口服中小剂量糖皮质激素或者中小剂量糖皮质激素配合免疫抑制剂治疗后皮疹均明显好转。结论嗜酸性粒细胞增多性皮炎皮疹表现无明显特异性,中小剂量糖皮质激素或者中小剂量糖皮质激素配合免疫抑制剂治疗效果较好。Objective To investigate the clinical characteristics,the laboratory examinations and the treatment methods of the eosinophilic dermatitis.Methods The clinical data of 29 patients with eosinophilic dermatitis admitted to the Department of Dermatology,Air Force Special Medical Center,PLA from January 2012 to December 2019 were retrospectively analyzed.Results Among the 29 patients,the male to female ratio was 3.1∶1,and the average age was(61.3±14.18)years old.Twenty-eight patients had generalized rashes,which could be mainly manifested in two types.One was infiltrated or swollen erythema,accounting for 41.4%;the other was generalized firm papules,nodules,with or without moss-like changes and dry desquamation,accounting for 31.0%.The laboratory examination showed that besides an obvious increase in eosinophils,85.2%of patients presented with elevated lactate dehydrogenase,and 63.0%of patients with elevated alpha-hydroxybutyrate decarboxylase.Through oral administration of low to medium dose of glucocorticoids alone or low to medium dose of glucocorticoids combined with immunosuppressive agents,the rashes were visibly improved.Conclusion The rash of eosinophilic dermatitis has no obvious specificity,and the treatment effect of low to medium dose of glucocorticoids or low to medium dose glucocorticoids combined with immunosuppressive agent obtains a preferable effect.

关 键 词：嗜酸性粒细胞增多 皮炎 治疗 临床分析 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]