重组人促卵泡激素联合重组人促黄体激素与尿促性素在卵泡期长方案促排卵中的临床效果比较  

Comparison of clinical effect of recombinant human follicle stimulating hormone combined with recombinant human luteinizing hormone and urinary gonadotropin in long protocol ovulation induction in follicular phase

作　　者：吴润香 李玲 岳林林 WU Run-xiang;LI Ling;YUE Lin-lin(Department of Reproductive and Genetic Medicine,Ganzhou Maternal and Child Health Hospital,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市妇幼保健院生殖与遗传科,江西赣州341000

出　　处：《中国当代医药》2021年第23期141-144,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(20202087)。

摘　　要：目的比较重组人促卵泡激素联合重组人促黄体激素与尿促性素在卵泡期长方案促排卵中的临床效果。方法回顾性分析赣州市妇幼保健院2018年5月—2019年12月收治的140例接受试管受精(IVF)助孕的卵泡期长方案促排卵患者的临床资料,按照治疗方案不同分为A组(73例)与B组(67例)。A组采用重组人促黄体激素(rLH)联合重组人促卵泡激素,B组采用尿促性素联合重组人促卵泡激素,比较两组的临床观察指标、治疗结局、生理指标。结果两组患者的促性腺激素(Gn)总量、Gn使用天数、正常受精率、优质胚胎率、囊胚形成率、妊娠率比较,差异无统计学意义(P>0.05);两组患者治疗前的内膜厚度、雌二醇、孕酮和促黄体生成素(LH)水平比较,差异无统计学意义(P>0.05);两种治疗后的内膜厚度,雌二醇,LH水平比较,差异无统计学意义(P>0.05)。两组治疗后的内膜厚度、LH、孕酮、雌二醇水平高于治疗前,差异有统计学意义(P<0.05)。结论对于卵泡期长方案促排卵的患者,采用重组人促卵泡激素+重组人促黄体激素与重组人促卵泡激素+尿促性素均可有效助孕,具有临床应用价值。其中尿促性素便宜,且可减少重组人促卵泡激素的用量,能够减轻患者的经济负担,值得临床推广应用。Objective To compare the clinical effect of recombinant human follicle stimulating hormone,recombinant human luteinizing hormone and urinary gonadotropin in long protocol ovulation induction in follicular phase.Methods The clinical data of 140 patients indergoing in vitro fertilization(IVF)with long follicular phase ovulation induction in Ganzhou Maternal and Child Health Hospital from May 2018 to December 2019 were retrospectively analyzed.According to the different treatment schemes,they were divided into group A(73 cases)and group B(67 cases).Group A was treated with recombinant human luteinizing hormone combined with recombinant human follicle stimulating hormone,and group B was treated with urinary gonadotropin combined with recombinant human follicle stimulating hormone.The clinical observation indexes,treatment outcome and physiological indexes of the two groups were compared.Results There was no significant difference in the total amount of gonadotropin(Gn),days of Gn use,normal fertilization rate,high-quality embryo rate,blastocyst formation rate and pregnancy rate between the two groups(P>0.05).There was no significant difference in endometrial thickness,estradiol,progesterone and luteinizing hormone(LH)levels between the two groups before treatment(P>0.05).The levels of endometrial thickness,LH,progesterone and estradiol of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).Conclusion For ovulation induction patients with long follicular period regimen,recombinant human follicle stimulating hormone combined with recombinant human luteinizing hormone or recombinant human follicle stimulating hormone combined with urinary gonadotropin can effectively assist pregnancy and have clinical application value.The urinary gonadotrophin is cheap,and can reduces the amount of recombinant human follicle-stimulating hormone,and reduces the economic burden of patients,so it can be popularized in clinical application.

关 键 词：重组人促卵泡激素 重组人促黄体激素 尿促性素 卵泡期 助孕 优质胚胎率 

分 类 号：R711.6[医药卫生—妇产科学]