孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床疗效及安全性研究  

Clinical Efficacy and Safety of Montelukast Sodium in the Treatment of Cough Variant Asthma in Children

作　　者：钟翠玲 ZHONG Cuiling(Hunnan District Hospital of Shenyang City,Shenyang 110168,China)

机构地区：[1]辽宁省沈阳市浑南区医院,辽宁沈阳110168

出　　处：《中国医药指南》2021年第21期42-43,共2页Guide of China Medicine

摘　　要：目的关于孟鲁司特钠对小儿咳嗽变异性哮喘进行治疗的临床效果和治疗安全性的评价。方法选择2018年1月至2019年2月来我院门诊部进行治疗的小儿咳嗽变异性哮喘64例患儿为研究对象,随机分为观察组与对照组,每组32例。两组患儿均进行常规的基础治疗,而本文的观察组患儿在常规治疗基础之上联合孟鲁司特钠进行治疗,比较两组患儿不同治疗的效果。结果观察组治疗总有效率为96.88%(31/32),对照组治疗总有效率为65.63%(21/32),P<0.05;观察组并发症发生率为6.25%(2/32),对照组并发证发生率为28.13%(9/32),P<0.05;对两组患儿经过不同治疗以后的咳嗽消失时间和肺部哮鸣音消失时间进行比较,观察组明显比对照组更短,P<0.05,差异存在统计学意义。结论对小儿咳嗽变异性哮喘在进行临床治疗的时候在常规治疗基础之上对患儿联合孟鲁司特钠进行治疗可以有效提高治疗的总有效率,并且具有一定的安全性,有效的缩短患儿的相关症状的改善时间,值得推广。Objective To evaluate the clinical efficacy and safety of treatment of pediatric cough variant asthma in montelukast sodium.Methods Sixtyfour children with cough variant asthma who came to the outpatient department of our hospital for treatment from January 2018 to February 2019 were selected as the research objects.They were randomly divided into observation group and control group,with 32 cases in each group.Both groups underwent routine basic treatment.The children in the observation group were treated with montelukast sodium on the basis of conventional treatment,and the effects of different treatments were compared between the two groups.Results The total effective rate of the observation group was 96.88%(31/32).The total effective rate of the control group was 65.63%(21/32),P<0.05.The complication rate of the observation group was 6.25%(2/32).The incidence of concurrent syndrome in the control group was 28.13%(9/32),P<0.05.The disappearance time of cough and the disappearance time of lung wheezing after different treatments were compared between the two groups.The observation group was significantly shorter than the control group,P<0.05.Conclusion In the clinical treatment of pediatric cough variant asthma,the combination of regular treatment and montelukast sodium can effectively improve the total effective rate of treatment,and it has certain safety and effective shortening of children.The time to improve the symptoms associated with it is worth promoting.

关 键 词：孟鲁司特钠 小儿咳嗽变异性哮喘 临床治疗效果 

分 类 号：R725.6[医药卫生—儿科]