卡贝缩宫素、米索前列醇和缩宫素用于预防选择性剖宫产产后出血的疗效  

Effect of Carbetocin,Misoprostol and Oxytocin in the Prevention of Postpartum Hemorrhage after Selective Cesarean Section

作　　者：张桂馨 ZHANG Guixin(Dandong Central Hospital,Dandong 118002,China)

机构地区：[1]丹东市中心医院,辽宁丹东118002

出　　处：《中国医药指南》2021年第21期54-56,共3页Guide of China Medicine

摘　　要：目的探讨卡贝缩宫素、米索前列醇和缩宫素对预防选择性剖宫产产后出血的疗效。方法选择本院2017年2月至2019年2月收治拟行剖宫产手术的132例产妇为研究对象,随机分为3组,每组44例。3组患者分别采用卡贝缩宫素(A组)、米索前列醇(B组)和缩宫素(C组)预防产后出血,观察3组子宫收缩效果、产后出血量、产后出血率及出血预防效果,并观察不良反应发生情况。结果A组产后出血量<500 mL比例为81.82%,B组为61.36%、C组为59.09%,3组产后出血量比较差异显著,P<0.05。A组出血预防有效率为86.36%、子宫收缩有效率为93.18%,额外缩宫剂使用率6.82%、产后出血率18.18%,B组分别为61.36%、77.27%、25.00%、38.64%,C组为65.91%、72.73%、22.73%、40.91%,均比较差异有统计学意义,P<0.05。不良反应发生率中,热感以B组18.18%偏高,腹痛以A组47.73%偏高,心悸以C组25.00%偏高,且3组热感、腹痛、心悸等发生率比较有统计学意义,P<0.05。结论卡贝缩宫素、米索前列醇和缩宫素对预防选择性剖宫产产后出血均可获得一定的效果,其中卡贝缩宫素效果更好,产后出血率低,利于保证产妇安全。Objective To explore the effects of carbetocin,misoprostol and oxytocin on the prevention of postpartum hemorrhage after selective cesarean section.Methods The 132 parturients who were admitted to our hospital from February 2017 to February 2019 who were planned to undergo cesarean section were selected as the research objects,and they were randomly divided into three groups,with 44 cases in each group.The three groups of patients were treated with carbetocin(group A),misoprostol(group B)and oxytocin(group C)to prevent postpartum hemorrhage.The effect of uterine contraction,the amount of postpartum hemorrhage,the rate of postpartum hemorrhage and hemorrhage prevention effect,and observe the occurrence of adverse reactions.Results The proportion of postpartum hemorrhage less than 500 mL in group A was 81.82%,group B was 61.36%,and group C was 59.09%.There was a significant difference in postpartum hemorrhage between the three groups,P<0.05.The effective rate of bleeding prevention in group A was 86.36%,the effective rate of uterine contraction was 93.18%,the use rate of extra uterine contraction was 6.82%,the rate of postpartum hemorrhage was 18.18%,and the rates of group B were 61.36%,77.27%,25.00%,38.64%,the rates of group C were 65.91%,72.73%,22.73%,40.91%,and the differences were statistically significant,P<0.05.In the incidence of adverse reactions,18.18%of the heat sensation was higher in group B,47.73%of the abdominal pain was higher in group A,and palpitations were higher than 25.00%in group C,and the incidence of heat,abdominal pain,and palpitations in the three groups was statistically significant significant,P<0.05.Conclusion Carbetocin,misoprostol and oxytocin can all have certain effects on the prevention of postpartum hemorrhage after selective cesarean section.Among them,carbetocin is more effective and has a low rate of postpartum hemorrhage,which helps to ensure the safety of the mother.

关 键 词：卡贝缩宫素 米索前列醇 缩宫素 剖宫产 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]