围绝经期AUB-O发病的高危因素及与IR的相关性分析  

High-risk factors of AUB-O in perimenopausal period and its correlation with IR

作　　者：马盛宗 马娟[2] 丁永慧[3] MA Shengzong;MA Juan;DING Yonghui(Maternal and Child Health Care Hospital of Yinchuan,Yinchuan 750001,China;Ningxia Medical University,Yinchuan 750004,China;Department of Gynecology,The General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏银川市妇幼保健院,宁夏银川750001 [2]宁夏医科大学,宁夏银川750004 [3]宁夏医科大学总医院妇科,宁夏银川750004

出　　处：《宁夏医学杂志》2021年第8期687-690,共4页Ningxia Medical Journal

基　　金：宁夏留学人员科技活动项目择优资助项目(2016494);宁夏自然科学基金项目(2019AAC03201);宁夏重点研发计划项目(2019BEH03005)。

摘　　要：目的探讨影响围绝经期排卵障碍性异常子宫出血(AUB-O)的高危因素以及与胰岛素抵抗的相关性。方法选取确诊为围绝经期AUB-O患者107例和非AUB-O患者105例,对其年龄、孕次、产次、BMI、腰臀比、既往月经紊乱史、职业、文化程度、运动习惯、饮食习惯、是否患高血压、高血压家族史、糖尿病、糖尿病家族史、月经紊乱家族史和胰岛素抵抗相关指标(血清胰岛素、空腹血糖、HOMA-IR、HOMA-β)等进行对比分析。结果107例围绝经期AUB-O患者与105例围绝经期非AUB-O患者一般资料对比分析结果显示,在BMI、WHR、既往月经紊乱史、运动习惯、饮食习惯、文化程度、糖尿病史等方面差异有统计学意义;而在年龄、职业、孕次、产次、高血压病史、家族高血压病史、家族糖尿病史、家族月经紊乱史等方面差异无统计学意义;胰岛素相关指标包括FPG、FINS、HOMA-IR、HOMA-β等方面差异均有统计学意义。围绝经期AUB-O影响因素的Logistic回归分析结果显示,HOMA-IR、FINS、HOMA-β、WHR、既往月经紊乱史、饮食习惯、运动习惯是围绝经期AUB-O患者的危险因素。结论胰岛素抵抗与围绝经期AUB-O的发生有明显的相关性;既往月经紊乱史、腰臀比、不良生活方式(运动习惯、饮食习惯)、HOMA-IR是围绝经期AUB-O发病的高危因素。Objective To investigate the relationship between insulin resistance and AUB-Oin perimenopausal period and to explore the high-risk factors affecting AUB-O in perimenopausal period.Methods A total of 107 patients with perimenopausal AUB-O and perimenopausal AUB-O were diagnosed as perimenopausal AUB-O patients based on medical history,physical signs and auxiliary examinations.A total of 105 patients with non-AUB-O at stage,their general information:(age,pregnancy times,parity,BMI,waist-to-hip ratio,past menstrual disorders,history,occupation,education level,exercise habits,eating habits,whether high blood pressure,family history of hypertension,diabetes,family history of diabetes,family history of menstrual disorders)and insulin resistance related indicators(serum insulin,fasting blood glucose,HOMA-IR,HOMA-β)were compared and analyzed.Results 107 cases of perimenopausal AUB-O patients and 105 non-AUB-O patients during the perimenopausal period were compared and analyzed.The results showed that there were statistically significant differences in BMI,WHR,history of menstrual disorders,exercise habits,eating habits,education level,diabetes history,etc.;there were no statistical differences in age,occupation,pregnancy times,parity,hypertension,family history of hypertension,family history of diabetes,family history of menstrual disorders,etc.;insulin-related indicators included FPG,FINS,HOMA-IR,HOMA-differences inβand other aspects were statistically significant.The logistic regression analysis of the influencing factors of AUB-O in perimenopause showed that HOMA-IR,history of menstrual disorders,WHR,FINS,HOMA-β,eating habits,and exercise habits were risk factors for patients with AUB-O in perimenopause.Conclusion There is a significant correlation between insulin resistance and AUB-O during perimenopause;and past menstrual disorders,waist-to-hip ratio,poor lifestyle(exercise habits,eating habits),and HOMA-IR are high risk factors for the onset of AUB-O during perimenopause.

关 键 词：围绝经期 异常子宫出血 胰岛素抵抗 排卵障碍 

分 类 号：R271.11[医药卫生—中医妇科学]