多参数MRI放射组学预测上皮性卵巢癌患者术前腹膜转移  

Multiparameter MRI radiomics predicts preoperative peritoneal metastasis in patients with epithelial ovarian cancer

作　　者：蔚晓玉 吴慧[1] 牛广明[1] 任嘉梁 蔚纳 钱洛丹 吴静[1] YU Xiaoyu;WU Hui;NIU Guangming;REN Jialiang;YU Na;QIAN Luodan;WU Jing(Department of Radiology,Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia,Huhhot 010050,China;GE Healthcare,Beijing 100176,China)

机构地区：[1]内蒙古医科大学附属医院影像诊断科,呼和浩特010050 [2]北京通用电气药业有限公司,北京100176

出　　处：《磁共振成像》2021年第8期44-48,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：内蒙古自治区自然科学基金项目(编号:2020MS08128)。

摘　　要：目的评价基于多参数磁共振成像(multiparameter magnetic resonance imaging,MP-MRI)的放射组学特征对上皮性卵巢癌腹膜转移的预测价值。材料与方法回顾性收集86例上皮性卵巢癌患者纳入研究,所有患者均行轴位脂肪抑制T2加权成像(fat suppression-T2 weighted imaging,FS-T2WI)、扩散加权成像(diffusion-weighted imaging,DWI)和动态增强(dynamic contrast enhanced,DCE)-T1WI扫描,从每个患者术前FS-T2WI、DWI和DCE-T1WI图像中提取定量成像特征,建立放射组学模型、临床模型;结合放射组学特征及临床病理危险因素,构建放射组学诺模图,通过受试者工作特性曲线、AUC、校准曲线和临床实用性来评估该放射组学诺模图的预测性能。结果来自MP-MRI组合序列的放射组学模型比单独来自FS-T2WI、DWI和DCE-T1WI的模型具有更高的AUC(0.865 vs.0.749、0.765、0.736)。诺模图(0.953)显示出比临床模型(0.819)和组学模型(0.865)更好的诊断效果。结论基于MP-MRI组合序列的放射组学诺模图对腹膜转移显示出良好的预测准确性,可用于术前识别上皮性卵巢癌患者的腹膜转移。Objective:To evaluate the predictive value of radiomics based on multi-parameter magnetic resonance imaging(MP-MRI)for epithelial ovarian cancer(EOC)peritoneal metastasis.Materials and Methods:A retrospective collection of 86 patients with EOC was included in the study.All patients underwent axial lipid suppression(FS)T2WI,diffusion weighted imaging(DWI)and dynamic enhancement(DCE)T1WI scans,and then underwent total double appendage resection.Quantitative imaging features were extracted from the preoperative FS-T2WI,DWI and DCE-T1WI images of each patient,and a radiomic model was established to evaluate the ability of radiomic features to distinguish peritoneal metastases.In addition,a clinical model was established.Finally,combined with radiomic characteristics and clinicopathological risk factors,a radiomic nomogram was constructed,and the receiver operating characteristic curve(ROC),area under the curve(AUC),calibration curve and clinical practicality to evaluate the predictive performance of the radiomics nomogram.Results:The radiomic model derived from the MP-MRI combined sequence had a higher AUC than the model derived from FS-T2WI,DWI,and DCE-T1WI alone(0.865 vs.0.749,0.765,0.736).The nomogram(AUC=0.953)showed a better diagnostic effect than the clinical model(AUC=0.819)and the omics model(AUC=0.865).The analysis of the decision curve shows that the nomogram has good clinical application value.Conclusions:The radiomic nomogram based on the combined sequence of MP-MRI shows good predictive accuracy for peritoneal metastasis.This non-invasive and reliable tool can be used to identify peritoneal metastases in EOC patients before surgery.

关 键 词：上皮性卵巢癌 腹膜转移 放射组学 磁共振成像 多参数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.31[医药卫生—诊断学]