流感病毒感染中炎症小体的激活和调控机制  

Activation and regulation mechanisms of the inflammasome in influenza virus infection

作　　者：林裕贵 李程颐 李培群 钟伟娟 林春秀 张增峰[1] LIN Yu-gui;LI Cheng-yi;LI Pei-qun;ZHONG Wei-juan;LIN Chun-xiu;ZHANG Zeng-feng(Department of Microbiology,Guangxi Medical University,Nanning 530021,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]广西医科大学微生物学教研室,南宁530021 [2]江南大学食品学院,无锡214122

出　　处：《中国人兽共患病学报》2021年第8期741-747,共7页Chinese Journal of Zoonoses

基　　金：国家自然科学基金项目(No.31660041);广西研究生教育创新计划项目(No.YCSW2020124)联合资助。

摘　　要：炎症反应是宿主抗流感病毒感染的一个重要过程,它可以诱导产生抗病毒的炎症微环境以减少病毒的复制和扩散,同时参与对流感病毒的适应性免疫反应,在机体抗流感病毒感染过程中至关重要。然而,过度的炎症反应同时也是流感病毒重症感染、甚至死亡的主要因素。研究表明,炎症小体作为炎症反应的重要启动和调节分子,介导IL-1β和IL-18的成熟和分泌并诱导了细胞焦亡,在流感病毒发病机制中起着重要的调节作用,因此,针对炎症小体的激活和调控也成为流感病毒治疗的一个新策略。The inflammatory response is an important process in the host defense against influenza virus infection,which can induce an antiviral inflammatory microenvironment,thus diminishing the replication and spread of the virus,and can participate in the adaptive immune response to the influenza virus.However,an excessive inflammatory response is also a major factor in severe influenza virus infection and even death.Studies have shown that the inflammasome,an important promoter and regulator of the inflammatory response,mediates the maturation and secretion of IL-1βand IL-18,and induces pyroptosis,which plays an important regulatory role in the pathogenesis of influenza virus.Hence,the activation and regulation of the inflammasome has become a new strategy for influenza virus treatment.

关 键 词：流感病毒 感染 炎症小体 激活 调控机制 

分 类 号：R373.1[医药卫生—病原生物学]