Nrf2在脑铁代谢中作用的研究进展  

Role of Nrf2 in brain iron metabolism

作　　者：高雅萱 宋顺晨 盛奕 芮同宇 罗承良[1] GAO Ya-xuan;SONG Shun-chen;SHENG Yi;RUI Tong-yu;LUO Cheng-liang(Department of Forensic Medicine,School of Biology&Basic Medical Sciences,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学基础医学与生物科学学院法医学系,江苏苏州215123

出　　处：《中国病理生理杂志》2021年第8期1499-1504,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81971163,No.81400999)。

摘　　要：神经细胞的铁代谢平衡对大脑的正常功能至关重要。很多脑部疾病常常伴随有脑铁代谢(brain iron metabolism)的紊乱。这种紊乱不加控制可以引起神经细胞的铁死亡(ferroptosis)--一种可调控性细胞死亡(regulated cell death,RCD)形式,其特征是铁过载引起的脂质过氧化(lipid peroxidation,LPO)积累。作为一种转录因子,核因子E2相关因子2(nuclear factor E2-related factor 2,Nrf2)调控许多与脑铁代谢和铁死亡相关的基因。Brain iron disorder is a severe metabolism disfunction in neurological homeostasis,with high morbidity and mortality.Transcription factor nuclear factor E2-related factor 2(Nrf2)is involved in the iron metabolism by controlling the activity of iron import,storage and export proteins in the brain.This review systematically summarizes the latest progress in targeting Nrf2 to mitigate iron metabolism dysfunction.Considering that Nrf2 relieves iron accumulation in the brain by changing the activity of enzymes/proteins related to iron metabolism and lipid peroxidation,Nrf2 represents a new direction for treatment of brain iron diseases/disorders.

关 键 词：核因子E2相关因子2 脑疾病 铁代谢 铁死亡 

分 类 号：R589.9[医药卫生—内分泌] R338[医药卫生—内科学]