Quality assessment of Jinhongtang Granule using UFLC-MS/MS and multivariate statistical analysis  

作　　者：Fan Wu Yu Zhang Yanling Qiao Ting Zhao Baojing Zhang Bangjiang Fang Xiaokui Huo Xiaochi Ma 

机构地区：[1]Institute of Integrative Medicine,College of Pharmacy,The Second Affiliated Hospital,Dalian Medical University,Dalian 116044,China [2]Department of Emergency,LongHua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China

出　　处：《Asian Journal of Traditional Medicines》2021年第4期191-202,共12页亚洲传统医药（英文）

基　　金：The authors thank National Key Research and Development Program of China(2018YFC1705900);National Natural Science Foundation of China(No.81903706);Distinguished professor of Liaoning Province(XLYC2002008);Science Foundation of Department of Education of Liaoning Province(LZ2020054)for financial support.

摘　　要：Jinhongtang is a traditional Chinese medicine formula composed of Rheum palmatum L.stem,Sargentodoxa cuneata stem,and Taraxacum mongolicum and is used for the treatment of sepsis.However,quality assessment method for Jinhongtang is not available.In present study,we developed a UFLC-MS/MS method to determine 16 analytes in 20 batches of home-made and commercial Jinhongtang.Multivariate statistical analysis revealed the significant differences in the quality of home-made and commercial Jinhongtang and the difference in the quality of home-made samples was more significant.The integrated strategy based on UFLC-MS/MS and multivariate statistical analysis provided a new basis for the overall quality assessment of Jinhongtang.

关 键 词：Jinhongtang quality assessment UFLC-MS/MS multivariate statistical analysis 

分 类 号：O17[理学—数学]