仁冬汤对心房颤动病人血清炎性因子及心房结构重构和功能的影响  

Effects of Rendong Decoction on Serum Inflammatory Factors and Atrial Structural Remodeling and Function in Patients with Atrial Fibrillation

作　　者：孙龙飞[1,2] 徐风燕[1] 安冬青[2,3] SUN Longfei;XU Fengyan;AN Dongqing(Affiliated Hospital of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830000,Xinjiang,China,Xinjiang Medical University,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆医科大学附属中医医院,乌鲁木齐830000 [2]新疆医科大学,乌鲁木齐830000 [3]新疆名医名方与特色方剂学重点实验室,乌鲁木齐830000

出　　处：《中西医结合心脑血管病杂志》2021年第16期2707-2711,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：新疆医科大学附属中医医院课题(No.ZYYZ201701)。

摘　　要：目的观察仁冬汤对心房颤动病人心房结构重构和功能、炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]的影响。方法选取2018年1月—2019年6月新疆维吾尔自治区中医医院收治的非瓣膜性心房颤动病人112例,采用随机数字表法分为对照组和治疗组,各56例。对照组给予达比加群酯胶囊和(或)琥珀酸美托洛尔缓释片治疗,治疗组在对照组基础上给予仁冬汤治疗。比较两组治疗前及治疗12周后心房结构指标[左室舒张末期内径(LVEDD)、左房内径(LAD)、右房内径(RAD)]和心房功能指标[左心房主动射血分数(LAAEF)]、炎性因子(CRP、IL-6、TNF-α)变化及临床疗效。结果治疗后,两组CRP、IL-6、TNF-α水平较治疗前均降低(P<0.05),且治疗组均低于对照组(P<0.05)。治疗12周后,两组LVEDD、LAD较治疗前降低,LAAEF较治疗前增加,且治疗组优于对照组,差异有统计学意义(P<0.05)。治疗后,两组中医单项症状心悸、胸闷、气短、乏力较治疗前降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗后,治疗组总有效率(94.64%)高于对照组(78.57%),两组比较差异有统计学意义(χ^(2)=5.014,P<0.05)。结论仁冬汤治疗心房颤动临床疗效确切,能明显降低病人血清炎性因子表达,抑制心房结构重构,改善心房功能。Objective To observe the clinical efficacy of Rendong Decoction in patients with atrial fibrillation and its effects of atrial structural remodeling and inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)].Methods One hundred and twelve patients with nonvalvular atrial fibrillation were randomly divided into the control group and the treatment group,with 56 cases in each group.The patients in the control group were treated with Dabigatran capsule and metoprolol succinate sustained-release tablets and the patients in the treatment group were treated with Rendong Decoction on the basis of the control group.The atrial structure indexes[left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD),right atrial diameter(RAD)],atrial function indexes[left atrial active ejection fraction(LAAEF)],inflammatory factors(CRP,IL-6,TNF-α),and clinical efficacy were compared between two groups before treatment and at 12 weeks after treatment.Results After treatment,the levels of CRP,IL-6,and TNF-αin two groups were decreased compared with those before treatment(P<0.05),and the levels in the treatment group were decreased more than those in the control group(P<0.05).After 12 weeks of treatment,LVEDD and LAD in two groups were decreased compared with those before treatment,LAAEF was increased compared with that before treatment(P<0.05),those in the treatment group were better than those in the control group(P<0.05).After treatment,the symptoms of traditional Chinese medicine such as palpitation,chest tightness,shortness of breath and fatigue in two groups were less than those before treatment(P<0.05),and those in the treatment group were better than those in the control group(P<0.05).The clinical efficacy of the treatment group was better than that of the control group(94.64%vs 78.57%,χ^(2)=5.014,P<0.05).Conclusion Rendong Decoction could treat of atrial fibrillation,effectively significantly reduce the expression of serum inflammatory factors in patients with atrial

关 键 词：心房颤动 仁冬汤 心房结构重构 心房功能 炎性因子 

分 类 号：R54[医药卫生—心血管疾病]