增龄与心力衰竭的研究进展  

Research progress in aging and heart failure

作　　者：赵阳[1] 商鲁翔 汤宝鹏[1] ZHAO Yang;SHANG Lu-Xiang;TANG Bao-Peng(Department of Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;Department of Cardiology, First Affiliated Hospital of Shandong First Medical University·Shandong Provincial Qianfoshan Hospital, Ji′nan, 250014, China)

机构地区：[1]新疆医科大学第一附属医院起搏电生理科·新疆心电生理与心脏重塑重点实验室,乌鲁木齐830054 [2]山东第一医科大学第一附属医院·山东省千佛山医院心内科,济南250014

出　　处：《中华老年多器官疾病杂志》2021年第8期623-627,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家重点研发计划(2016YFC0900905)。

摘　　要：心力衰竭(简称心衰)发病率及患病率随年龄增加而逐渐升高,研究显示增龄可独立于其他疾病造成心肌损伤,最终导致心衰发生。本文综述了增龄导致心脏的结构、功能及表型变化,着重叙述了增龄导致心衰的机制研究进展,包括心肌细胞衰老、血管衰老、细胞外基质重塑、神经内分泌失衡及非编码RNA改变等,并介绍了几种针对增龄性心衰的新兴治疗措施。The incidence and prevalence of heart failure(HF)gradually increase with age.Studies have shown that aging can cause myocardial injury independent of other diseases and eventually lead to HF.This article reviews structural,functional and phenotypic changes of heart caused by aging with emphasis on the research progress in the mechanism of HF caused by aging,including cardiomyocyte senescence,vascular senescence,extracellular matrix remodeling,neuroendocrine imbalance,and non-coding RNA changes.It also introduces several new therapeutic measures for aging-related HF.

关 键 词：衰老 心力衰竭 衰老心血管事件链 致病机制 

分 类 号：R541.61[医药卫生—心血管疾病]