Bile acid signaling and bariatric surgery  

作　　者：Jingyan Tian Silvia Huang Siming Sun Lili Ding Eryun Zhang Yanjun Liu Wendong Huang 

机构地区：[1]National Clinical Research Center for Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Department of Endocrinology and Metabolism,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Department of Diabetes Complications and Metabolism,Beckman Research Institute of City of Hope,Duarte,CA,USA [3]Eugene Robert Summer Program,City of Hope,Duarte,CA,USA [4]Shanghai Key Laboratory of Compound Chinese Medicines and the Ministry of Education(MOE)Key Laboratory of Standardization of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai,China

出　　处：《Liver Research》2017年第4期208-213,共6页肝脏研究（英文）

基　　金：This workwas supported by the National Cancer Institute 2R01CA139158,John Hench Foundation,George Schaeffer Foundation,Chinese National Natural Science Foundation(81270935);Transform Medicine Innovation Foundation of Shanghai Jiao Tong University School of Medicine(15ZH2001);Research Project Funded by the Shanghai Municipal Health Bureau(20114301);the Fund of the Key Laboratory of Stem Cell Biology of Chinese Academy of Sciences(201601).

摘　　要：The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic complications.Bariatric surgical procedures,such as Roux-en-Y gastric bypass(RYGB)and vertical sleeve gastrectomy(VSG),currently provide the most effective treatment for obesity and type 2 diabetes(T2D),as well as for non-alcoholic steatohepatitis(NASH).However,the underlying mechanisms of the beneficial effects of bariatric surgery remain elusive.Recent studies have identified bile acids as potential signaling molecules involved in the beneficial effects of bariatric surgery.This review focuses on the most recent studies on the roles of bile acids and bile acid receptors Farnesoid X receptor(FXR)and G protein-coupled bile acid receptor 5(TGR5)in bariatric surgery.We also discuss the possibility of modulating bile acid signaling as a pharmacological therapeutic approach to treating obesity and its associated metabolic complications.

关 键 词：Bile acid(BA) Bariatric surgery Farnesoid X receptor(FXR) G protein-coupled bile acid receptor 5 (TGR5) MICROBIOTA 

分 类 号：R58[医药卫生—内分泌]