镍催化的吲哚2-位二氟烷基化反应的研究  

Nickel-catalyzed C(2)—H Difluoroalkylation of Indoles with Fuoroalkyl Halides

作　　者：赖胤龙 张琦 张洁蓥 李健华 严绍熙 杜克斯 罗建民 LAI Yin-long;ZHANG Qi;ZHANG Jie-ying;LI Jian-hua;YAN Shao-xi;DU Ke-si;LUO Jian-min(College of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, China;School of Environment and Energy, South China University of Technology, Guangzhou 510640, China)

机构地区：[1]韶关学院化学与土木工程学院,广东韶关512005 [2]华南理工大学环境与能源学院,广东广州510655

出　　处：《合成化学》2021年第8期667-672,共6页Chinese Journal of Synthetic Chemistry

基　　金：广东省自然科学基金面上项目(2021A1515010185);广东省科技创新战略专项项目(“大专项+任务清单”)(韶科〔2020〕44号);广东省普通高校科研项目(2018KQNCX236);韶关市科技计划项目(2018sn047)。

摘　　要：报道了一种用简单有效的镍催化吲哚化合物和卤代氟试剂,实现吲哚2-位C—H的二氟烷基化和全氟烷基化的反应。在该催化体系中,不论是N-取代吲哚衍生物,还是N-非取代的吲哚衍生物,均可获得较高收率。初步的机理研究表明:反应归属自由基途径。An efficient and mild Ni-catalyzed C—H difluoromethylation and perfluoroalkylation of indoles with commonly available fluoroalkyl halides has been developed.This novel transformation has demonstrated both free indole derivatives and N-substituted indole derivatives could be used to obtain the desired products in good yields.Preliminary study suggests that radical pathway was involved in the catalytic cycle.

关 键 词：吲哚 镍 催化 氟烷基化 N-取代 合成 机理 自由基 

分 类 号：O62[理学—有机化学]