内皮细胞特异性分子-1的生物学特性及其在相关疾病中的作用  

The Biological Characteristics of Endothelial Cell Specific Molecule-1 and its Role in Related Diseases

作　　者：郭慧雯 潘占海 王青青 张晓璇[1] 马征[1] GUO Hui-wen;PAN Zhan-hai;WANG Qing-qing;ZHANG Xiao-xuan;MA Zheng(Department of Neurology,Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China)

机构地区：[1]承德医学院附属医院神经内科,河北承德067000

出　　处：《医学信息》2021年第17期61-66,共6页Journal of Medical Information

摘　　要：内皮细胞特异性分子-1是由内皮细胞分泌的一种新型内皮细胞功能障碍分子,其具有广泛的生物学活性,通过多种途径参与到调节炎症反应、细胞的黏附迁移、血管生成等病理生理过程中。近年研究发现,内皮细胞特异性分子-1与肿瘤、心血管系统疾病、呼吸系统疾病、皮肤病等多种类型疾病密切相关,为上述疾病的诊断、严重程度、预后及靶向治疗等提供了有力的理论依据,具有非常重要的临床意义和生物学价值。本文主要就内皮细胞特异性分子-1的生物学特性及其在相关疾病中的研究进展进行综述,旨在为进一步深入研究提供理论依据。Endothelial cell specific molecule-1 is a new type of endothelial cell dysfunction molecule secreted by endothelial cells.It has a wide range of biological activities and participates in the regulation of inflammation,cell adhesion and migration,angiogenesis,and other pathophysiology through various channels.In the process.Recent studies have found that endothelial cell specific molecule-1 is closely related to tumors,cardiovascular diseases,respiratory diseases,skin diseases and other types of diseases.It provides a strong theoretical basis for the diagnosis,severity,prognosis and targeted therapy of the above diseases,and has very important clinical significance and biological value.This article mainly reviews the biological characteristics of endothelial cell-specific molecule-1 and its research progress in related diseases.It aims to provide a theoretical basis for further in-depth research.

关 键 词：内皮细胞特异性分子-1 肿瘤 呼吸系统疾病 心血管系统疾病 皮肤病 

分 类 号：R34[医药卫生—基础医学]