感染相关性泛发性脓疱型银屑病临床分析  

Clinical Analysis of Infection-related Generalized Pustular Psoriasis

作　　者：祝琳琳[1] 孙晓冬[1] 张婷婷 孙晓杰[1] Zhu linlin;Sun Xiaodong;Zhang Tingting;Sun Xiaojie(Shenyang 7th People's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市第七人民医院,辽宁沈阳110000

出　　处：《中国中西医结合皮肤性病学杂志》2021年第4期353-357,共5页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：辽宁省自然基金资助计划项目(编号:2020-MS-326);沈阳市中青年科技创新人才支持计划项目(编号:RC200417)。

摘　　要：目的分析感染相关性泛发性脓疱型银屑病(GPP)临床资料,并探讨其相关性。方法回顾性分析2014年9月—2019年8月皮肤科收治的176例GPP患者的临床资料,采用SPSS 19.0统计软件,将176例分为儿童组和成人组,分析总结其感染性诱因、实验室检查、抗生素疗效及扁桃体切除后的疗效。结果儿童组与成人组分别与同期寻常型银屑病平均住院日12.8 d相比较差异有统计学意义(P<0.05);儿童组与成人组内感染组与非感染组白细胞计数(WBC)、C反应蛋白(CRP)及降钙素原(PCT)间差异均有统计学意义(P<0.05);儿童组年龄、WBC、CRP及PCT与住院日间相关性弱(r分别为0.252、0.272、0.048、0.113,均r<0.3);扁桃体炎是最常见的感染因素;使用抗生素组的银屑病皮损面积和严重程度指数(PASI)评分降低明显,差异有统计学意义(P<0.01);使用抗生素组与非使用抗生素组总有效率比较差异无统计学意义(χ2=0.37,P>0.05);扁桃体切除术后病情有改善,减轻范围在40%~90%。结论尽早、及时发现感染症状,完善WBC、CRP、PCT,应用抗生素及扁桃体切除术均对GPP病情缓解起积极正向作用。Objective In order analyze the clinical data of infection-related generalized pustular psoriasis(GPP)and to explore its correlation.Methods A retrospective analysis was made to the clinical data of 176 cases who were diagnosed with GPP in the department of dermatology from September 2014 to August 2019 and statistical analysis was made with the software SPSS 19.0.Totally 176 cases were divided into children group and adult group.The infectious inducement,laboratory examination,antibiotic and tonsillectomy efficacy of the two groups were analyzed.Results The children and adult group were compared with the average of hospitalization 12.8 days for psoriasis vulgaris,the differences were statistically significant(P<0.05).There had a statistical differences in white blood cell(WBC),C-reactive protein(CRP)and procalcitonin(PCT)between the infected group and the non-infected group(P<0.05).The age,white blood cell,CRD and procalcitonin had little correlation with inpatient day in the children group (r=0.252,0.272,0.048,0.113,r<0.3). Tonsillitis was the most common infectious factor. The psoriasis area and severity index score of the antibiotic group decreased dramatically,and the differences were statistically significant (P<0.01). There were no prominent differences in the total effective rate between the antibiotics treatment group and the non-antibiotic treatment group (χ2=0.37,P>0.05). After tonsillectomy,the patient's condition improved with a reduction range from 40% to 90%. Conclusion Early and timely detection of infection symptoms,examination of WBC,CRP,PCT,antibiotics and tonsillectomy all play a positive role in the remission of GPP.

关 键 词：泛发性脓疱型银屑病 感染 抗生素 扁桃体 预后 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]