倍他司汀有关物质的合成  

Synthesis of Betahistine Related Substances

作　　者：尹超 Yin Chao(Shanghai Zhongxi Sunve Pharmaceutical Co.,Ltd.,Shanghai 201419,China)

机构地区：[1]上海中西三维药业有限公司,上海201419

出　　处：《广东化工》2021年第12期47-49,共3页Guangdong Chemical Industry

摘　　要：倍他司汀是一种新型组胺H1受体的弱激动剂,具有扩张毛细血管,舒张前毛细血管括约肌,增加前毛细血管微循环血流量的作用。临床主要用于治疗美尼尔综合征(内耳眩晕症),血管性头痛及脑动脉硬化,也可用于治疗急性缺血性脑血管疾病等。有关物质研究是药品质量研究的关键,其含量是反映药品纯度的直接指标。本文报道了5个倍他司汀有关物质的合成方法,以期为倍他司汀的产品质量及其有关物质的研究提供参考。Betahistine is a new type of histamine H1 receptor weak agonist.It has the function of expanding capillaries,relaxing the anterior capillary sphincter,and increasing the blood flow of the anterior capillary microcirculation.It is mainly used for the treatment of Meniere's syndrome(inner ear vertigo),vascular headache and cerebral arteriosclerosis.It can also be used for the treatment of acute ischemic cerebrovascular diseases.Related substance research is one of the key items in drug quality research,and its content is a direct indicator of drug purity.This article reports five synthetic methods of betahistine related substances,hoping to provide reference for the pharmacological research of betahistine and related substances.

关 键 词：倍他司汀 H1受体激动剂 美尼尔综合征 有关物质 合成方法 

分 类 号：TQ[化学工程]