烟酰胺核苷酸临床研究进展及化学制备方法  

Clinical Research and Chemical Preparation Progress of Nicotinamide Nucleotide

作　　者：邓军 罗统有 刘道甫 许俊伟 罗明亮 姚礼伦 谭志聪 Deng Jun;Luo Tongyou;Liu Daofu;Xu Junwei;Luo Mingliang;Yao Lilun;Tan Zhicong(Guangdong Xianqiang Pharmaceutical Co.,Ltd.,Guangzhou 510900;Guangdong Zhongsheng Pharmaceutical Co.,Ltd.,Dongguan523320,China)

机构地区：[1]广东先强药业有限公司,广东广州510900 [2]广东众生药业股份有限公司,广东东莞523320

出　　处：《广东化工》2021年第12期98-100,88,共4页Guangdong Chemical Industry

摘　　要：在各种类型的烟酰胺腺嘌呤二核苷酸(辅酶Ⅰ、NDAH)前体中,迄今为止只有烟酰胺单核苷酸(NMN)具有更好的药代动力学和药理学性质。这种特殊的分子在临床上证明具有广大的潜在治疗用途。包括其在细胞生化功能,心脏保护,糖尿病,阿尔茨海默病等。本综述旨在描述烟酰胺单核苷酸的药理作用,应用前景和化学制备方法,为新药研发打下基础。Among all kinds of precursors of Nicotinamide Adenine Dinucleotide(Coenzyme A,NDAH),only Nicotinamide Nucleoside Monophosphate(NMN)has better pharmacokinetic and pharmacological properties.This special molecule has been clinically proved to have a wide range of potential therapeutic uses.Including its biochemical function,heart protection,diabetes,Alzheimer's disease and so on.The purpose of this review is to describe the pharmacological effects and application prospects of nicotinamide mononucleotides,so as to lay a foundation for the research and development of new drugs.

关 键 词：烟酰胺腺嘌呤二核苷酸 烟酰胺单核苷酸 药理活性 临床研究 制备方法 

分 类 号：TQ[化学工程]