血清β_(2)-MG、LDH、ALB、CRP水平检测对多发性骨髓瘤临床应用价值的分析  

Clinical application value of serum levels ofβ_(2)-MG,LDH,ALB,and CRP in multiple myeloma

作　　者：蔡晓虹[1] 杨梓华 曾银珠 王晓珍[1] Cai Xiaohong;Yang Zihua;Zeng Yinzhu;Wang Xiaozhen(Department of Haematology,The Third Affiliated Hospital of Sun Yat-sen University,Sun Yat-sen Institute of Hematology,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院血液内科中山大学血液病研究所,广州510630

出　　处：《国际医药卫生导报》2021年第15期2345-2347,共3页International Medicine and Health Guidance News

摘　　要：目的探讨血清β_(2)微球蛋白(β_(2)-MG)、乳酸脱氢酶(LDH)、血清白蛋白(ALB)、C反应蛋白(CRP)水平检测对多发性骨髓瘤(MM)的临床应用价值。方法采用完全随机设计,选取中山大学附属第三医院血液内科2018年4月至2021年3月收治的MM患者25例(男性12例,女性13例,中位年龄63岁),列为MM组;选取2021年1月肾内科收治的肾功能减退患者20例(男性11例,女性9例,中位年龄62岁),列为肾内科组,同期血液科收治的非MM血液病患者20例(男性12例,女性8例,中位年龄44岁),列为血液科组。对3组患者的β_(2)-MG、LDH、ALB、CRP水平进行两两比较,并做统计学分析。结果肾内科组患者的β_(2)-MG为16.16(6.21,30.24)mg/L,MM组、血液科组患者分别为4.20(2.45,7.85)mg/L、2.58(2.32,4.32)mg/L,肾内科组与MM、血液科组相比较,差异均有统计学意义(均P<0.001),MM组与血液科组的β_(2)-MG相比较,差异无统计学意义(P>0.05);而MM、肾内科及血液科组患者的血清LDH、ALB、CRP水平两两相比较,差异均无统计学意义(P>0.05)。结论血清β_(2)-MG、LDH、ALB、CRP的检测对MM有重要的临床应用价值,但以上指标水平升高在肾功能减退、血液病中也可存在,单独检测较易出现诊断误差。Objective To investigate the clinical value of detecting serum levels ofβ_(2)microglobulin(β_(2)-MG),lactic dehydrogenase(LDH),serum albumin(ALB),and C-reactive protein(CRP)in multiple myeloma(MM).Methods The study design was a completely random design.A total of 25 MM patients who were 27-82 years old and were admitted to Department of Haematology,The Third Affiliated Hospital of Sun Yat-sen University from April 2018 to March 2021,including 12 males and 13 females,were selected as an MM group;20 renal dysfunction patients who were admitted to Department of Nephrology of our hospital in January 2021,including 11 males and 9 females,were set as a nephrological department group,with a median age of 63;and 20 patients with non-MM hematologic diseases who were admitted to Department of Hematology at our hospital,including 12 males and 8 females,were selected as a hematological department group,with a median age of 44.The levels ofβ_(2)-MG,LDH,ALB,and CRP were compared between these 3 groups,and were statistically analyzed.Results Theβ_(2)-MG level in the nephrological department group[16.16(6.21,30.24)mg/L]was statistically different from thosein theMM group[4.20(2.45,7.85)mg/L]and the hematological department group[2.58(2.32,4.32)mg/L],both P<0.05.There were no statistical differences in the serum levels of LDH,ALB,and CRP between these 3 groups(all P>0.05).Conclusion The detection of serumβ_(2)-MG,LDH,ALB,and CRP has important clinical application value in multiple myeloma,but the elevated levels of these indicators can also exist in patients with renal dysfunction and hematologic diseases,and the single detection is likely to cause diagnostic errors.

关 键 词：多发性骨髓瘤 β_(2)-MG LDH ALB CRP 

分 类 号：R733.3[医药卫生—肿瘤]