扬州市婴儿发育性髋关节发育不良发病率及流行病学特征研究  

Incidence and epidemiological characteristics of developmental dysplasia of the hip in Yangzhou

作　　者：王玉欢[1] 王加宽[1] 盛春勇[1] 陈智博[1] 李俊[1] Wang Yuhuan;Wang Jiakuan;Sheng Chunyong;Chen Zhibo;Li Jun(Department of Pediatric Orthopedics,Yangzhou Maternal and Child Health Care Hospital,Affiliated Hospital of Medical College of Yangzhou University,Yangzhou 225002,China)

机构地区：[1]扬州市妇幼保健院小儿骨科,扬州大学医学院附属医院,225002

出　　处：《中华小儿外科杂志》2021年第8期727-731,共5页Chinese Journal of Pediatric Surgery

基　　金：江苏省妇幼健康科研项目(F201633);扬州市社会发展-重大科技示范项目(YZ2017065);扬州市"十三五"科教强卫领军人才(创新团队)(LJRC201823)。

摘　　要：目的:研究扬州市婴儿发育性髋关节发育不良(developmental dysplasia of the hip,DDH)发病率及流行病学特征,为早发现、早诊断、早治疗提供依据。方法:基于扬州市DDH早期筛查三级网络,用调查表收集2017年1月至2019年6月扬州市妇幼保健院行髋关节超声筛查的42~48 d婴儿检查结果及相关资料,分析扬州市DDH发病率及流行病学特征。筛查统一采用Graf髋关节超声诊断分型法,分型≥Ⅱa-者诊断为DDH。计数资料采用例/%表示,左右侧发病率对比采用χ2检验,风险因素与DDH发病关系应用多因素Logistic回归分析,P<0.05为差异有统计学意义。结果:本研究共纳入婴儿8853例。其中,男4519例,女4334例。诊断为DDH的婴儿有106例(1.2%)。左侧DDH发病率为0.87%(77/8853),高于右侧0.41%(36/8853),两者比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,女性(OR=5.422,95%CI:3.219~9.133)及第1胎(OR=1.817,95%CI:1.169~2.823)是DDH发病的风险因素。襁褓不当、羊水量异常、合并畸形等因素因相关样本较少、且无DDH病例,无法列入统计对比。结论:扬州市42~48 d婴儿DDH发病率为1.20%(106/8853),左侧多于右侧,女性及第1胎为DDH的风险因素。Objective To explore the incidence and epidemiological characteristics of infantile developmental dysplasia of the hip(DDH)in Yangzhou and provide basis for early detection,early diagnosis and early treatment.Methods From January 2017 to June 2019,the examination results and relevant data of hip ultrasound screening on infants aged 42-48 days were collected by a questionnaire based upon a three-level network of early DDH screening in Yangzhou.The incidence and epidemiological characteristics of DDH in Yangzhou were analyzed.Graf hip ultrasound imaging was employed for screening.DDH was diagnosed with a classification of≥IIa-.Counting data were expressed by n/%.The incidence of left side versus right side was compared byχ2 test.Multivariate logistic regression analysis was utilized for examining the relationship between risk factors and the incidence of DDH.P<0.05 was deemed as statistically significant.Results Among 8853 infants,there were 4519 boys and 4334 girls.And 106 infants were diagnosed as DDH with an incidence of 1.20%.The incidence of DDH rate at left was higher than that at right[(0.87%,77/8853)vs.(0.41%,36/8853)]and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis indicated that female(OR=5.422,95%CI:3.219-9.133)and first child(OR=1.817,95%CI:1.169-2.823)were the risk factors of DDH.Improper swaddling,abnormal amniotic fluid volume and combined malformation could not be included for statistical comparison since there were few related cases and no DDH case.Conclusions The incidence of DDH in infants aged 42-48 days in Yangzhou is 1.20%(106/8853).And DDH is more prone to occur at left side.Girl and first borns are the risk factors of DDH.

关 键 词：流行病学 发育性髋关节发育不良 婴儿 

分 类 号：R726.8[医药卫生—儿科]