生长因子对新生儿坏死性小肠结肠炎胃肠道保护作用的相关研究  

Summary of growth factors on gastrointestinal tract protective effects in neonatal necrotizing enterocolitis

作　　者：潘晓雪 沈淳 Pan Xiaoxue;Shen Chun(Department of Pediatric Surgery,Children's Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China)

机构地区：[1]国家儿童医学中心复旦大学附属儿科医院小儿外科,上海201102

出　　处：《中华小儿外科杂志》2021年第8期759-764,共6页Chinese Journal of Pediatric Surgery

基　　金：国家自然科学基金(81873849)。

摘　　要：新生儿坏死性小肠结肠炎(neonatal necrotizing enterocolitis,NEC)是一种危及新生儿,尤其是早产儿生命的胃肠道急症。近年来,国内NEC发病率呈现上升趋势。因此,对NEC胃肠道保护作用的研究仍显重要。生长因子是一类调控细胞生长、发育的生物活性物质,能以特定方式改善肠道功能。本文现就生长因子对新生儿坏死性小肠结肠炎胃肠道保护作用相关研究的进展及临床意义做一综述。As a common neonatal gastrointestinal emergency,neonatal necrotizing enterocolitis(NEC)occurs frequently in premature infants.Since the incidence of NEC has an upward trend in China,it is imperative to explore the gastrointestinal tract protection effects of NEC.Growth factors are bioactive substances capable of regulating cellular growth and development and improving intestinal functions in some specific ways.This review summarized the latest research advances of growth factors on gastrointestinal tract protective effects in necrotizing enterocolitis and the relevant clinical significance.

关 键 词：坏死性小肠结肠炎 胃肠道 生长因子 保护作用 

分 类 号：R722.1[医药卫生—儿科]