2016-2019年江苏地区无偿献血人群HTLV-I/II流行情况调查  

Prevalence of Human T-Cell Lymphotropic Virus Type 1 and 2 among Blood Donors in Jiangsu from 2016 to 2019

作　　者：陈慧[1] 冯涛 朱绍汶 蔡丽娜[1] 陈宝安 CHEN Hui;FENG Tao;ZHU Shao-Wen;CAI Li-Na;CHEN Bao-An(Jiangsu Province Blood Center,Nanjing 210042,Jiangsu Province,China;Department of Hematology,Zhongda Hospital Southeast University,Nanjing 210009,Jiangsu Province,China)

机构地区：[1]江苏省血液中心,江苏南京210042 [2]东南大学附属中大医院血液内科,江苏南京210009

出　　处：《中国实验血液学杂志》2021年第4期1308-1311,共4页Journal of Experimental Hematology

摘　　要：目的:调查江苏地区(南京、苏州、徐州)无偿献血人群人类嗜T淋巴细胞病毒(HTLV-I/II)感染流行情况。方法:对2016-2019年江苏省四家血站(江苏省血液中心、南京市红十字血液中心、苏州市中心血站、徐州市中心血站)共408 262例无偿献血者样本进行HTLV-I/II抗体ELISA筛查,将初筛阳性样本统一送至国家卫生健康委临床检验中心进行RT-PCR和Western blot确认。结果:经HTLV-I/II抗体ELISA筛查共检出阳性82例,初筛阳性率为0.20‰(82/408 262),经确认,HTLV-I型阳性3例,确诊阳性率为0.74/100 000(3/408 262)。3名HTLV-I阳性献血者均为育龄期女性重复献血者。结论:江苏地区属于HTLV低流行区域,制定合理的HTLV血液筛查策略可进一步降低输血传播该病毒的风险。Objective: To investigate the prevalence of human T-cell lymphotropic virus( HTLV) type-I/II infection among voluntary blood donors in Jiangsu( Nanjing,Suzhou,Xuzhou). Methods: From 2016 to 2019,408 262 samples of voluntary blood donors from four blood stations in Jiangsu Province( Jiangsu Province Blood Center,Nanjing Red Cross Blood Center,Suzhou Central Blood Station,and Xuzhou Central Blood Station) were screened for HTLV-I/II antibody by ELISA. The positive samples were sent to National Center for Clinical Laboratories for confirmation by RTPCR and Western blot. Results: The positive rate of HTLV-I/II screened by ELISA was 0. 20‰( 82/408 262),and three HTLV-I positive samples were confirmed. The prevalence of HTLV-1 infection was 0. 74 per 100 000( 3/408262). All three donors were female repeated blood donors of childbearing ages. Conclusion: Jiangsu is a low prevalence area of HTLV,and a reasonable blood screening strategy for HTLV can further reduce the risk of transfusion-transmitted virus infection.

关 键 词：江苏 无偿献血者 人类嗜T淋巴细胞病毒-I/II 流行率 输血安全 

分 类 号：R457.1[医药卫生—治疗学]