自戕性肺损伤的机制和防治研究进展  

Research advances on the mechanisms and prevention and treatment of patient self-inflicted lung injury

作　　者：任志国 朱峰 Ren Zhiguo;Zhu Feng(Department of Respiratory Medicine,No 971 Hospital of PLAN,Qingdao 266071,China;Department of Burn Surgery,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]解放军海军第971医院呼吸内科,青岛266071 [2]海军军医大学第一附属医院烧伤外科,上海200433

出　　处：《中华烧伤杂志》2021年第8期801-804,共4页Chinese Journal of Burns

基　　金：国家重点研发计划“干细胞及转化研究”重点专项(2019YFA0110601);长海医院教学研究与改革重点项目(CHJG2019002)。

摘　　要：研究显示,因过度自主呼吸努力引起的肺损伤,即患者自戕性肺损伤(patient self-inflicted lung injury,P-SILI),是具有强烈自主呼吸的行机械通气的急性呼吸窘迫综合征(ARDS)患者发生机械通气相关性肺损伤、机械通气相关性膈肌功能障碍的重要表现形式和可能机制。本文综述了P-SILI概念、潜在发生机制、临床意义和防治等,以期为临床ARDS管理提供更多思路。Researches have shown that lung injury due to excessive spontaneous breathing effort,that is,patient self-inflicted lung injury(P-SILI),may be the important manifestation and possible mechanism of ventilation-associated lung injury and ventilation-induced diaphragmatic dysfunction in acute respiratory distress syndrome(ARDS)patients who were mechanically ventilated with intense spontaneous breathing.This paper reviews the concept of P-SILI,possible occurrence mechanism,clinical significance,and prevention and treatment,in order to provide more ideas for clinical ARDS management.

关 键 词：呼吸窘迫综合征 成人 呼吸机所致肺损伤 自戕性肺损伤 自主呼吸 呼吸努力 

分 类 号：R726[医药卫生—儿科] R64[医药卫生—临床医学]