卡前列素氨丁三醇联合垂体后叶素治疗产后出血的效果分析  

Analysis of the effect of carboprost tromethamine combined with pituitrin in the treatment of postpartum hemorrhage

作　　者：何煊 代炳梅[1] HE Xuan;DAI Bing-mei(Obstetrics and Gynecology Department,Dongguan Maternal and Child Health Hospital,Dongguan 523000,China)

机构地区：[1]广东省东莞市妇幼保健院妇产科,523000

出　　处：《中国现代药物应用》2021年第16期24-27,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨卡前列素氨丁三醇联合垂体后叶素治疗产后出血的疗效、安全性及对患者凝血功能的影响。方法1234例产后出血患者,按随机数字表法分为对照组和观察组,每组617例。对照组行卡前列素氨丁三醇治疗,观察组行卡前列素氨丁三醇+垂体后叶素治疗。对比两组治疗效果、用药后出血情况、治疗前后凝血功能情况、不良反应发生情况。结果观察组治疗总有效率为97.57%,高于对照组的93.35%,差异有统计学意义(P<0.05)。观察组止血时间(16.13±4.27)h短于对照组的(35.25±5.34)h,差异有统计学意义(P<0.05)。用药后0.5、2、24 h,观察组出血量分别为(123.86±11.37)、(258.28±18.49)、(296.54±14.58)ml,少于对照组的(186.41±16.74)、(435.62±21.66)、(547.37±15.35)ml,差异有统计学意义(P<0.05)。治疗后,观察组纤维蛋白原(FIB)(3.27±0.82)g/ml低于对照组的(4.02±0.75)g/ml,凝血酶时间(TT)、活化部分凝血活酶时间(APTT)分别为(19.22±4.24)、(40.34±12.36)s,均短于对照组的(26.57±5.73)、(49.33±11.27)s,差异有统计学意义(P<0.05)。观察组不良反应发生率为2.76%,低于对照组的5.02%,差异有统计学意义(P<0.05)。结论卡前列素氨丁三醇+垂体后叶素应用于产后出血治疗疗效显著,可迅速抑制出血,改善凝血功能,有效降低不良反应发生率,值得在临床上推广。Objective To discuss the efficacy and safety of carboprost tromethamine combined with pituitrin in the treatment of postpartum hemorrhage,and its influence on coagulation function of patients.Methods A total of 1234 cases of postpartum hemorrhage were divided into a control group and an observation group according to random numerical table,with 617 cases in each group.The control group was treated with carboprost tromethamine,and the observation group was treated with carboprost tromethamine and pituitrin.The therapeutic effect,bleeding after medication,coagulation function before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.57%,which was higher than 93.35%of the control group,and the difference was statistically significant(P<0.05).The hemostasis time of the observation group was(16.13±4.27)h,which was shorter than(35.25±5.34)h of the control group,and the difference was statistically significant(P<0.05).The bleeding volume at 0.5,2,and 24 h after medication in the observation group were(123.86±11.37),(258.28±18.49)and(296.54±14.58)ml,which were shorter than(186.41±16.74),(435.62±21.66)and(547.37±15.35)ml in the control group,and the difference was statistically significant(P<0.05).After treatment,the fibrinogen(FIB)(3.27±0.82)g/ml in the observation group was lower than(4.02±0.75)g/ml in the control group,and the thrombin time(TT)(19.22±4.24)s and activated partial thromboplastin time(APTT)(40.34±12.36)s were shorter than(26.57±5.73)and(49.33±11.27)s in the control group.All the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 2.76%,which was lower than 5.02%in the control group,and the difference was statistically significant(P<0.05).Conclusion Application of carboprost tromethamine and pituitrin has remarkable efficacy on the treatment of postpartum hemorrhage,and it can quickly inhibit bleeding,improve coagulation fu

关 键 词：卡前列素氨丁三醇 垂体后叶素 产后出血 疗效 

分 类 号：R714.461[医药卫生—妇产科学]