芥子气中毒生物标志物溯源检测技术研究进展  

Research progress on retrospective detection method of biomarkers of sulfur mustard.

作　　者：刘昌财 程茜[2] 刘石磊 Liu Changcai;Cheng Xi;Liu Shilei(State Key Laboratory of NBC Protection for Civilian,Beijing 102205,China;The Laboratory of Analytical Chemistry,Research Institute of Chemical Defence,Beijing 102205,China)

机构地区：[1]国民核生化灾害防护国家重点实验室,北京102205 [2]防化研究院分析化学实验室,北京102205

出　　处：《分析仪器》2021年第4期11-16,共6页Analytical Instrumentation

摘　　要：芥子气(HD)属于糜烂性毒剂,在第一次世界大战被作为化学战剂使用。HD具强烈的细胞毒作用,能使皮肤和各种组织产生起泡、糜烂和坏死等中毒损伤症状。本文综述了HD中毒机理、中毒后体内生物标志物的检测方法及其研究进展。熟悉掌握可靠的HD中毒机理和溯源检测方法,对于指证HD的使用和改善HD染毒人员的医疗救治具有重要指导意义。HD is a blistering agent used as a chemical warfare agent in World War I.HD has a severe cytotoxic effect and can make skin and various tissues produce blister,erosion,necrosis and other toxic damage symptoms.This paper reviews the research progress of the mechanism of HD poisoning and the detection methods of biomarkers in vivo after poisoning.Knowing and grasping the reliable HD poisoning mechanism as well as its retrospective detection method are of great guiding significance for the identification of HD abuse and the improvement of the medical treatment of people exposed to HD.

关 键 词：中毒溯源 生物标志物 糜烂性毒剂 分析检测方法 

分 类 号：R827.174[医药卫生—临床医学]