多萜醇N,N′-二乙酰壳二糖的合成  

Synthesis of the Dolichol Linked N,N′-Diacetylchitobiose

作　　者：陈征辉 晁强 高晓冬[1] 王宁[1] Chen Zhenghui;Chao Qiang;Gao Xiaodong;Wang Ning(School of Biotechnology,Jiangnan University,Wuxi,Jiangsu 214122,China)

机构地区：[1]江南大学生物工程学院,江苏无锡214122

出　　处：《化学世界》2021年第8期473-478,共6页Chemical World

基　　金：国家自然科学基金(No.21807048);国家自然科学基金(No.21778023);江苏省自然科学基金(No.BK20170174)资助项目。

摘　　要：以全乙酰壳二糖为原料,经过脱乙酰基,磷酸化和去苄基得到七乙酰壳二糖-1-α-磷酸;聚戊烯醇经过不对称加氢,磷酸化得到多萜醇磷酸,与七乙酰壳二糖-1-α-磷酸偶联后脱去乙酰基得到多萜醇N,N′-二乙酰壳二糖。目标化合物多萜醇N,N′-二乙酰壳二糖经1H NMR,13C NMR,31P NMR和基质辅助激光解吸-飞行时间质谱(MALDI-TOF-MS)表征。Heptaacetylchitobiosyl-1-α-phosphate was synthesized from octaacetylchitobiose via deacetylation,phosphorylation and debenzylation.Dolichyl phosphate was synthesized from polyprenol via asymmetric hydrogenation and phosphorylation.Heptaacetylchitobiosyl-1-α-phosphate and dolichyl phosphate were utilized for the condensation reaction and the product was deacetylated to give the target compound of dolichol linked N,N′-diacetylchitobiose.The structures of the product and intermediates were characterized by 1H NMR,13C NMR,31P NMR and matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS).

关 键 词：多萜醇 不对称加氢反应 多萜醇N N′-二乙酰壳二糖 

分 类 号：O629.9[理学—有机化学]