健脾补肾方对骨质疏松性骨折患者骨折区影像学参数的影响  

Effect of Jianpi Bushen Recipe on Imaging Parameters of Fracture Zone foRPatients with Osteoporotic Fractures

作　　者：纪木强 张兆华[1] 李伟强[1] 翁天才[1] 郑泓[1] 欧阳敏仪 曾玲玲 JI Muqiang;ZHANG Zhaohua;LI Weiqiang(Sanshui Hospital,Foshan Hospital of Traditional Chinese Medicine Attached to Guangzhou University of Traditional Chinese Medicine,Foshan Guangdong 528100,China)

机构地区：[1]广州中医药大学附属佛山市中医院三水医院,广东佛山528100

出　　处：《四川中医》2021年第7期155-158,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察健脾补肾方对骨质疏松性椎体压缩骨折患者骨折区影像学参数的影响。方法:纳入我院2018年1月~2020年1月间90例骨质疏松性椎体压缩骨折患者,采用随机数字表法分为观察组、对照组各45例。两组患者均行椎体成形术(PVP),并口服阿法骨化醇软胶囊,观察组在此基础上辅以健脾补肾方治疗。比较两组治疗12周后临床疗效,及治疗前、治疗12周后中医症候积分、疼痛程度[视觉模拟评分表(VAS)]评分、骨痂生长评分、骨折区影像学参数(骨密度、椎体前缘高度比值)、血清骨代谢指标[β胶原降解产物(β-CTX)、甲状旁腺素(PTH)、血清骨钙素(BGP)、1型前胶原氨基端延长肽(P1NP)]。结果:治疗12周后,观察组治疗总有效率高于对照组(P<0.05);两组中医症候积分、疼痛VAS评分均较治疗前降低,且观察组低于对照组(P<0.05);两组骨痂密度、骨痂量、骨痂边缘、断端边缘骨痂生长评分均较治疗前提高,且观察组高于对照组(P<0.05);两组骨密度、椎体前缘高度比值均较治疗前提高,且观察组高于对照组(P<0.05);两组血清β-CTX、PTH水平均较治疗前降低,且观察组低于对照组,BGP、P1NP水平均较治疗前提高,且观察组高于对照组(P<0.05)。结论:健脾补肾方用于骨质疏松性椎体压缩骨折术后辅助治疗可提高疗效,缓解椎体疼痛,改善骨代谢,促进骨折愈合。Objective:To explore the effect of Bupi Jianshen Decoction on imaging parameters of fracture zone foRpatients with osteoporotic vertebral compression fractures.Methods:A total of 90 patients with osteoporotic vertebral compression fractures in ouRhospital from January 2018 to January 2020 were selected and randomly divided into an observation group and a controlled group,45 cases in each group.The two groups of patients underwent vertebroplasty(PVP),and oral Alfacalcidol Soft Capsule,the observation group on the basis of supplemented with Jianpi Bushen Decoction.AfteR12 weeks of treatment,the clinical efficacy,TCM symptom score,VAS score,callus growth score,imaging parameters of fracture area(bone mineral density,anterior vertebral height ratio)and serum bone metabolism indexes were compared between the two groups[β-Collagen degradation products(β-CTX),parathyroid hormone(PTH),Serum Osteocalcin(BGP),and N-terminal pro collagen 1(p1np)].Results:AfteR12 weeks of treatment,the total effective rate of treatment in the observation group was higheRthan that in the controlled group(P<0.05).The scores of TCM syndromes and pain VAS in the two groups were loweRthan those before treatment,and the scores of the observation group were loweRthan those of the controlled group(P<0.05).The callus growth scores of callus density,callus volume,callus edge and broken end edge in the two groups were all increased compared to before treatment,and the scores of the observation group were higheRthan those of the controlled group(P<0.05).The bone density and ratio of anterioRvertebral body height in the two groups were higheRthan those before treatment,and the two indexes in the observation group were higheRthan those in the controlled group(P<0.05).The levels of serumβ-CTX and PTH in the two groups were decreased compared with those before treatment,and the levels of the observation group were loweRthan those of the controlled group,and the levels of BGP and P1NP were improved compared with those before treatment,and the levels of th

关 键 词：骨质疏松性椎体压缩骨折 健脾补肾方 影像学 骨代谢 

分 类 号：R274.1[医药卫生—中医骨伤科学]