早期激素干预对脓毒症患儿炎症因子及并发症的影响  

Effect of early hormone intervention on inflammatory factors and complications in children with sepsis

作　　者：王运初 傅文华 王颂华 付莎 Wang Yunchu;Fu Wenhua;Wang Songhua;Fu Sha(The people’s Hosptial of Liuyang)

机构地区：[1]浏阳市人民医院

出　　处：《实用休克杂志（中英文）》2021年第1期21-23,共3页Journal of Practical Shock

摘　　要：目的探讨早期激素干预对脓毒症患儿炎症因子释放及并发症的影响。方法选取本院2019年1月~2020年12月收治的60例脓毒症患儿作为研究对象,其中2020年1月前的30例患儿采用常规治疗;2020年1月后的30例患儿则在常规治疗的基础上加用甲基强的松龙治疗。评价两组患儿的临床治疗效果,并比较两组患儿治疗前后的炎症因子(TNF-α、IL-6、IL-10)变化及并发症发生情况。结果与对照组相比,观察组患儿的临床治疗总有效率明显增加(P <0.05)。两组患儿治疗前的各项炎症因子指标水平均未见明显的统计学差异(P>0.05)。治疗后两组患儿的炎症因子指标均较治疗前明显改善,其中观察组患儿变化更为明显(P<0.05)。对照组治疗期间并发症发生率为10.00%,观察组为6.67%,组间比较未见明显统计学差异(χ^(2)=0.000,P=1.000)。结论对脓毒症患儿进行早期激素干预,不仅有助于提高临床治疗效果,还能减少炎症因子释放,且具有较高的安全性。Objective To investigate the effect of early hormone intervention on inflammatory factors and complications in children with sepsis.Methods 60 cases of children with sepsis in our hospital from January 2019 to December 2020 were selected as the research objects,of which30 cases before January 2020 were treated with conventional treatment;30 cases after January 2020 were treated with Methylprednisolone on the basis of the control group.The clinical effects of the two groups were evaluated,and the levels of inflammatory factors(TNF-α,IL-6,IL-10)before and after treatment were compared between the two groups.Results Compared with the control group,the total effective rate of the observation group was significantly increased from73.33% to 93.33%,and the difference was statistically significant(P< 0.05).There was no significant difference in the levels of inflammatory factors between the two groups before treatment(P>0.05).After treatment,the inflammatory factor indexes of the two groups were significantly improved compared with those before treatment,and the improvement degree of the observation group was more superior,and the differences were statistically significant(P< 0.05).There was no significant difference between the two groups(χ^(2)=0.000,P=1.000).Conclusions Early hormone intervention in children with sepsis is not only helpful to improve the clinical treatment effect,but also can significantly improve the level of inflammatory factors and it has high security.

关 键 词：早期激素干预 脓毒症 炎症因子 并发症 

分 类 号：R720.597[医药卫生—急诊医学]