EB病毒与干燥综合征发病机制的关系研究进展  

Study advances in relationship between Epstein-Barr virus and pathogenesis of Sjögren′s syndrome

作　　者：王晶[1] 李成荫[1] 王莎莎[1] 朱丰林 戴敏[1] WANG Jing;LI Chengyin;WANG Shasha;ZHU Fenglin;DAI Min(Department of Rheumatology,Chongqing Municipal Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院风湿病科,400021

出　　处：《重庆医学》2021年第16期2835-2838,共4页Chongqing medicine

基　　金：国家自然科学基金项目(81804086);重庆市科委项目(cstc2017jxj1130033,cstc2019 jcyj-msxmX0714);重庆市科研院所绩效激励引导专项(cstc2018jxj1130016)。

摘　　要：干燥综合征(SS)发病机制复杂,可累及全身多个脏器。EB病毒(EBV)感染被认为是SS发病的危险因素,可通过干扰素途径、涎腺异位淋巴结构、分子模拟及CD8^(+)T淋巴细胞缺乏等多种方式参与SS发病。本文就EB病毒参与SS的发病机制作一综述,为SS发病机制的研究提供依据和参考。The pathogenesis of Sjögren′s syndrome(SS)is complex,which can involve multiple organs in the whole body.Epstein Barr virus(EBV)infection is considered to be a risk factor for SS.EBV is involved in the pathogenesis of SS through multiple modes such as interferon pathway,heterotopic lymphoid structure of salivary gland,molecular simulation and CD8^(+)T cell deficiency.This paper reviewed the pathogenesis of EBV participation in SS to provide a basis and references for further pathogenesis researches on SS.

关 键 词：EB病毒 干燥综合征 发病机制 自身免疫 

分 类 号：R373[医药卫生—病原生物学] R392.1[医药卫生—基础医学]