肝X受体β基因多态性与肺炎脓毒症患者预后的关联研究  

Association of genetic variations of the liver X receptor β gene with clinical prognosis of sepsis caused by pneumonia

作　　者：刘瑜 王立群 黄方 陈阳希 郭蕾 万文辉 张兴虎 Liu Yu;Wang Liqun;Huang Fang(First Department of Cadre Ward,General Hospital of Eastern Theater Command PLA,Nanjing 210002,China)

机构地区：[1]解放军东部战区总医院干部病房一科,南京210002 [2]解放军东部战区总医院伤病员管理科,南京210002

出　　处：《中华保健医学杂志》2021年第4期343-345,共3页Chinese Journal of Health Care and Medicine

基　　金：国家自然科学基金青年项目(81701890);全军保健专项课题(17BJZ17);后勤保障面上项目(CLB18J030)。

摘　　要：目的探讨华东汉族人群肝X受体β(liver X receptorβ,LXRβ)基因多态性与肺炎脓毒症患者临床转归的相关性。方法选取2014年2月~2015年2月解放军东部战区总医院收治的194例肺炎脓毒症患者,对其LXRβ基因上6个常见单核苷酸多态性(SNP)位点进行基因分型。在不同遗传模式下,采用非条件logistic回归方法分析各位点基因型与脓毒症临床转归的相关性。结果rs2695121在共显性和隐性遗传模式下与肺炎脓毒症患者死亡风险增加相关(P=0.0074、0.0099)。没有基因多态性与脓毒性休克和器官功能障碍相关。结论LXRβ基因多态性与肺炎脓毒症患者死亡风险相关。Objective To explore the association of LXRβ gene polymorphisms with clinical outcomes of sepsis in the Han population of East China.Methods We continuously collected 194 septic patients caused by pneumonia from February 2014 to February 2015 in our hospital.Six common SNPs in the LXRβ gene were genotyped.Unconditioned logistic regression analysis was used to explore the association of the LXRβ gene polymorphisms with clinical outcomes of sepsis.Results For rs2695121,the variation associated with increased risk of death in codominant and recessive model with P value 0.0074 and 0.0099 respectively.No mutation was correlated with organ dysfunction or septic shock.Conclusion LXRβ genetic polymorphisms may play a role in the clinical outcomes of sepsis caused by pneumonia in the Han population of East China.

关 键 词：脓毒症 肝X受体β 单核苷酸多态性 

分 类 号：R563.1[医药卫生—呼吸系统]