正交实验设计优化藤黄酸脂质微泡的制备工艺  

Orthogonal Experimental Design to Optimize the Preparation of Gambogic Acid Lipid Microbubbles

作　　者：潘娅[1] 郑德俊 Pan Ya;Zheng Dejun(South China University of Technology,Guangzhou 510640;The Second Affiliated Hospital of South China University of Technology,Department of Traditional Chinese Medicine,Guangzhou First People's Hospital,Guangzhou 510405,China)

机构地区：[1]华南理工大学化学与化工学院制药工程系,广东广州510640 [2]华南理工大学附属第二医院广州市第一人民医院中医科,广东广州510405

出　　处：《广东化工》2021年第13期5-6,共2页Guangdong Chemical Industry

基　　金：广东省2016年省科技发展专项资金项目(2016A030313469);华南理工大学探索性实验项目(C9192036)。

摘　　要：目的:考察藤黄酸脂质微泡的制备工艺。方法:采用正交实验设计法,以包封率为指标,优化藤黄酸脂质微泡的制备工艺。结果:最佳制备工艺条件为:药脂比为1∶4,卵磷脂与胆固醇质量比为4∶1,搅拌速度为200 rpm·min-1,温度为50℃。结论:该工艺简单可行,可有效地保留藤黄酸,提高藤黄酸在制剂中的稳定性。Objective: To investigate the preparation process of Gambogic acid lipid microbubbles. Method: The orthogonal experimental design method was used to optimize the preparation process of Gambogic acid lipid microbubbles based on the encapsulation rate. Results: The best preparation process conditions are: the drug-to-lipid ratio is 1∶4, the mass ratio of lecithin to cholesterol is 4∶1, the stirring speed is 200 rpm·min-1, and the temperature is 50 ℃. Conclusion: The process is simple and feasible, can effectively retain Gambogic acid and improve the stability of Gambogic acid in the preparation.

关 键 词：藤黄酸 微泡 制备 正交实验 优化 

分 类 号：R283.6[医药卫生—中药学]